Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4CD25 Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor.

CD4CD25Foxp3T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.

Interleukin-5 Mediates Parasite-Induced Protection against Experimental Autoimmune Encephalomyelitis: Association with Induction of Antigen-Specific CD4CD25 T Regulatory Cells.

Objective: To examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia. We hypothesize that, in parasite infections, IL-5 also promotes expansion of antigen-specific T regulatory cells that control autoimmunity.

Methods: larvae were used to infect Lewis rats prior to induction of EAE by myelin basic protein.