Synopsis of recent research by authors named "Paul L Durham"
- Paul L Durham's recent research focuses on the effects of dietary supplementation with grape seed extract (GSE) on trigeminal pain mechanisms, particularly in relation to conditions like chronic temporomandibular joint disorder (TMD) and migraine, showcasing GSE's potential to modulate protein expression and pain signaling pathways.
- Findings indicate that GSE can inhibit mechanical nociception and trigeminal sensitization through biological mechanisms involving GABAergic and endocannabinoid receptors, suggesting its role as a beneficial non-pharmacological option for managing orofacial pain and migraine conditions.
- Durham's work also emphasizes the importance of understanding neurophysiological changes related to migraine and TMD through both preclinical models and clinical applications, contributing to a broader integrative approach in pain management involving nutraceuticals.
