Publications by authors named "Paul Klaver"
Article Synopsis
- Rapid vaccine development was essential for controlling the COVID-19 pandemic, and understanding vaccine-related physiological responses is key for fostering trust in medical practices.
- This study focused on analyzing changes in breathing rate, heart rate, skin temperature, and menstrual cycle phases in over 17,000 participants in the Netherlands before and after COVID-19 vaccination.
- Results showed short-term increases in breathing and heart rates after vaccination but no long-term effects, indicating that vaccines do not lead to chronic physiological issues.
Article Synopsis
- The study examined sex-specific differences in physiological responses to COVID-19 using data from 1,163 participants monitored with a wearable device that measured breathing rate, heart rate, heart rate variability, and skin temperature.
- Findings revealed that men experienced more significant physiological changes during COVID-19 infection compared to women, including greater increases in skin temperature and breathing rate, as well as greater decreases in heart rate variability.
- The research highlights the importance of considering sex as a biological variable in health technologies and contributes to the understanding of personalized medicine approaches based on these physiological differences.
Early At-Home Measurement of Adalimumab Concentrations to Guide Anti-TNF Precision Dosing: A Pilot Study.
Eur J Drug Metab Pharmacokinet
July 2023
Article Synopsis
- Adalimumab underdosing can lead to ineffective treatment for rheumatic and inflammatory bowel diseases, prompting a study to forecast its concentrations early in therapy using population pharmacokinetic modeling.
- A literature search identified pharmacokinetic models, and patient samples were analyzed to predict steady state levels of adalimumab after the first dose, evaluating predictive performance through error metrics.
- The study included 36 patients, showing a 75% concordance between predicted and actual drug levels, and confirmed that early measurements can effectively predict future drug concentrations during treatment initiation.
Objectives: We investigated machinelearningbased identification of presymptomatic COVID-19 and detection of infection-related changes in physiology using a wearable device.
Design: Interim analysis of a prospective cohort study.
Setting, Participants And Interventions: Participants from a national cohort study in Liechtenstein were included.
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial.
Trials
October 2021
Objectives: It is currently thought that most-but not all-individuals infected with SARS-CoV-2 develop symptoms, but the infectious period starts on average 2 days before the first overt symptoms appear. It is estimated that pre- and asymptomatic individuals are responsible for more than half of all transmissions. By detecting infected individuals before they have overt symptoms, wearable devices could potentially and significantly reduce the proportion of transmissions by pre-symptomatic individuals.
View Article and Find Full Text PDFA prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial.
Trials
June 2021
Article Synopsis
- - The study aims to evaluate the effectiveness of wearable devices and self-reported symptom tracking in detecting SARS-CoV-2 infections, especially in asymptomatic individuals, potentially reducing transmission rates.
- - Two algorithms will be tested: one that combines data from the Ava bracelet and daily symptom reports, and another that relies solely on symptom reporting.
- - The trial is designed as a randomized, single-blinded crossover, where participants will experience both conditions in different time periods, allowing for comparison of each algorithm's performance in identifying infections.
Adverse Event: A drug interaction leading to higher exposure to cyclosporine.
Drugs Implicated: Cyclosporine and ticagrelor.
The Patient: A 49-year-old man with a stable renal graft, managed with cyclosporine with stable trough blood concentrations for several years, was treated with ticagrelor for unstable angina pectoris.
Objective: To study the effectiveness of two laser techniques clinically used to fragment renal stones: fragmenting technique (FT) and popcorn technique (PT).
Methods: Phantom stones were placed in a test tube filled with water, mimicking a renal calyx model. A Holmium:YAG laser was used for fragmentation using both techniques.
The therapeutic efficacy of two bis(thiosemicarbazonato) copper complexes, glyoxalbis[N4-methylthiosemicarbazonato]Cu(II) [Cu(II)(gtsm)] and diacetylbis[N4-methylthiosemicarbazonato]Cu(II) [Cu(II)(atsm)], for the treatment of prostate cancer was assessed in cell culture and animal models. Distinctively, copper dissociates intracellularly from Cu(II)(gtsm) but is retained by Cu(II)(atsm). We further demonstrated that intracellular H2gtsm [reduced Cu(II)(gtsm)] continues to redistribute copper into a bioavailable (exchangeable) pool.
View Article and Find Full Text PDFBackground: Gentamicin-polymethylmethacrylate (PMMA) beads release gentamicin gradually, and high concentrations develop only locally. It is unclear how frequent and in which patients gentamicin serum concentrations are measurable and possibly lead to toxicity. The aim of this study was to investigate the measurability of gentamicin serum concentrations after the implantation of gentamicin-PMMA beads and to assess the nephrotoxicity of these beads.
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