Publications by authors named "Paul Kern"
Article Synopsis
- The unfolded protein response (UPR) plays a key role in liver function, particularly how disturbances in the endoplasmic reticulum (ER) can disrupt metabolic balance.
- Creld2 is identified as a protein that helps manage stress responses in cells, enhancing protein folding and aiding recovery from ER stress.
- The absence of Creld2 leads to improper UPR regulation, resulting in liver fat accumulation, especially in males, indicating that chronic ER stress may contribute to liver diseases like fatty liver and steatohepatitis.
CRELD1 is a pivotal factor for heart development, the function of which is unknown in adult life. We here provide evidence that CRELD1 is an important gatekeeper of immune system homeostasis. Exploiting expression variance in large human cohorts contrasting individuals with the lowest and highest CRELD1 expression levels revealed strong phenotypic, functional and transcriptional differences, including reduced CD4 T cell numbers.
View Article and Find Full Text PDFInactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.
Biochim Biophys Acta Mol Cell Biol Lipids
July 2018
The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level. We show here by qRT-PCR and transcriptome analyses that several transcripts of genes involved in lipid metabolism and cell division are differentially regulated in livers of CerS2 H/A mice. Thus, very long chain ceramides produced by CerS2 are required for transcriptional regulation of target genes.
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