Investigating the Antibacterial Efficiency and Mechanism of Indole- and Naphthalimide-Mediated Benzimidazoles: Membrane Damage, Metabolic Inactivation, and Oxidative Stress against .

Resistance by bacteria to available antibiotics is a threat to human health, which demands the development of new antibacterial agents. Considering the prevailing conditions, we have developed a series of naphthalimide/indole benzimidazoles with diverse amines and aryl rings to avoid the molecular framework of conventional drug molecules to overcome the cross-resistance issue. Most of the synthesized compounds, especially electron-withdrawing and halide substituents, show broad-spectrum activity against both Gram-positive and Gram-negative bacterial strains.

First dosimetric evaluation of clinical raster-scanned proton, helium and carbon ion treatment plan delivery during simultaneous real-time magnetic resonance imaging.

This work presents an experimental dosimetric evaluation of raster-scanning particle beam delivery during simultaneous in-beam magnetic resonance (MR) imaging. Using an open MR scanner at an experimental treatment room, radiochromic film comparisons for protons, helium and carbon ions, each with and without simultaneous in-beam cine MR imaging, yielded 2D gamma pass rates ≥ 98.8 % for a 3 % / 1.

Geriatric hip fracture with proximal upper extremity fracture increases morbidity and mortality.

Objectives: This study investigates differences in medical, surgical, and hospital-related outcomes within 30 days between patients sustaining a hip fracture with and without concomitant upper extremity fracture. Further subgroup analysis based on fracture location was also completed.

Design: Retrospective review.

Benefits of Testosterone Replacement Therapy in Hypogonadal Males.

Importance: Hypogonadism is defined by consistently low serum testosterone levels in conjunction with clinical symptoms. Testosterone replacement therapy (TRT) can be used to achieve physiologic levels of testosterone. Testosterone deficiency is associated with increased mortality and poorer health outcomes.

Optimizing sustainable energy management in grid connected microgrids using quantum particle swarm optimization for cost and emission reduction.

The global shift towards decentralized energy systems, driven by the integration of distributed generation technologies and renewable energy sources, underscores the critical need for effective energy management strategies in microgrids. This study proposes a novel multi-objective optimization framework for grid-connected microgrids using quantum particle swarm optimization (QPSO) to address the dual challenges of minimizing operational costs and reducing environmental emissions. The microgrid configuration analyzed includes renewable energy sources like photovoltaic panels and wind turbines, along with conventional energy sources and battery storage.

Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease.

BackgroundAlzheimer's disease (AD) and its monoclonal antibody therapies are associated with brain vasculitis and amyloid-related imaging abnormalities. The naturally-formed epoxides (EpFAs) of polyunsaturated fatty acids (PUFAs), such as 11,12-epoxyeicosatetraenoic acid (EEQ), are anti-inflammatory and pro-resolution mediators, which are increased by dietary supplementation with ω-3 PUFAs. EpFAs are, however, enzymatically hydrolyzed by soluble epoxide hydrolase (sEH) in AD patients' macrophages in vivo and in vitroObjectiveTo repair amyloid-β 1-42 (Aβ) degradation by AD macrophages using the inhibitors of a) soluble epoxide hydrolase (sEHIs), termed TPPU and EC5026, together with EpFAs, or b) STING pathway termed H-151.

Column Chromatography-Free Synthesis of Spirooxindole and Spiroindanone-Based Naphthalimides as Potent G4 Stabilizers and HSA Binders for Elevating Anticancer Potential.

G-quadruplex (G4) DNA plays a pivotal regulatory role in fundamental biological processes, integral for governing cellular functions such as replication, transcription, and repair in living cells. Within cancer cells, G4 DNA exerts an impact on the expression of crucial genes such as , effectively repressing its activity when structured within its promoter region. Therefore, employing molecular scaffolds to target these structures offers an attractive strategy for altering their functions.

Identification of and genes and their expression profiling under biotic and abiotic stress in pigeon pea ( [L.] Millspaugh).

The methylation- demethylation dynamics of RNA plays major roles in different biological functions, including stress responses, in plants. mA methylation in RNA is orchestrated by a coordinated function of methyl transferases (writers) and demethylases (Erasers). Genome-wide analysis of genes involved in methylation and demethylation was performed in pigeon pea.

Deciphering Binding Potential of Naphthalimide-Coumarin Conjugate with c-MYC G-Quadruplex for Developing Anticancer Agents: A Spectroscopic and Molecular Modeling Approach.

It has been well accumulated that G-quadruplex (G4-DNA) has great anticancer relevance, and various heterocyclic moieties have been synthesized and examined as potent G4-DNA binders with promising anticancer activity. Here, we have synthesized a series of naphthalimide-triazole-coumarin conjugates by substituting various amines and further examine their anticancer activity against 60 human cancer cell lines at 10 μM. One and five dose concentration results reveal low values of MG-MID GI for compounds including (3.

Revisiting the electrophysiological correlates of valence and expectancy in reward processing - A multi-lab replication.

Two event-related brain potential (ERP) components, the frontocentral feedback-related negativity (FRN) and the posterior P300, are key in feedback processing. The FRN typically exhibits greater amplitude in response to negative and unexpected outcomes, whereas the P300 is generally more pronounced for positive outcomes. In an influential ERP study, Hajcak et al.

Non-screw glenoid augmentation constructs for shoulder instability with bone loss: A biomechanical assessment of static and elastic cerclage constructs.

Purpose: This study aims to compare the biomechanical performance of elastic and static suture-based cerclage systems to traditional screw constructs in the setting of modeled glenoid bony augmentation.

Methods: Biomechanical testing was conducted on polyurethane cellular foam blocks modeling a 20 % glenoid defect repaired with a coracoid graft. Constructs consisted of an elastic suture-based cerclage, static suture-based cerclage, and a two-screw construct.

Selective Recognition of Oncogene Promoter C-Myc G-Quadruplex: Design, Synthesis, and In Vitro Evaluation of Naphthalimide and Imidazo[1,2-]pyrazines for Their Anticancer Activity.

c-Myc is a transcription factor that is overexpressed in most human cancers. Despite its challenging nature, we have developed a series of naphthalimide-imidazopyrazine conjugates to target c-Myc. The library of synthesized derivatives was tested for their anticancer activity against a nine-panel of cancer cell lines.

Prevalence and predictors of infected diabetic foot ulcers (DFU) and DFU-related osteomyelitis amongst industrial workers wearing occupational safety footwear.

Professionals like deep-miners and factory-workers wear specialized safety-shoes to protect against occupational hazards (OF). The risk factors, clinico-microbiologic profile and complications of diabetic foot ulcers (DFU) in these professionals remain unexplored. A cross-sectional observational study was conducted to describe the unique clinico-microbiologic profile of DFU in those wearing occupational-footwear (OF) and find risk factors for DFU related osteomyelitis in them.

Body Temperature Regulation in Domestic Dogs After Agility Trials: The Effects of Season, Training, Body Characteristics, Age, and Genetics.

An animal's body mass is said to be indirectly related to its rate of heat loss; that is, smaller animals with higher surface area to volume tend to lose heat faster than larger animals. Thus, thermoregulation should be related to body size, however, generalizable patterns are still unclear. Domestic dogs are a diverse species of endothermic mammals, including a 44-fold difference in body size.

VISTA-induced tumor suppression by a four amino acid intracellular motif.

VISTA is a key immune checkpoint receptor under investigation for cancer immunotherapy; however, its signaling mechanisms remain unclear. Here we identify a conserved four amino acid (NPGF) intracellular motif in VISTA that suppresses cell proliferation by constraining cell-intrinsic growth receptor signaling. The NPGF motif binds to the adapter protein NUMB and recruits Rab11 endosomal recycling machinery.

Unlocking the Antibacterial Potential of Naphthalimide-Coumarins to Overcome Drug Resistance with Antibiofilm and Membrane Disruption Ability against .

Resistance by bacteria to available antibiotics is a threat to human health, which demands the development of new antibacterial agents. Considering the prevailing conditions, we have developed a library of new naphthalimide-coumarin moieties as broad-spectrum antibacterial agents to fight against awful drug resistance. Preliminary studies indicate that compounds and display excellent antibacterial activity against , exceeding the performance of marketed drug amoxicillin.

Nanoencapsulated Essential Oils for Post-Harvest Preservation of Stored Cereals: A Review.

Cereal grains are frequently attacked by microorganisms and insects during storage and processing, which negatively affects their quality, safety, and market value. Therefore, protecting stored grains from microbial contamination is crucial for food industries, farmers, public health associations, and environmental agencies. Due to the negative impact of synthetic gray chemicals, antimicrobial plant-based essential oils (EOs) can serve as alternative, safer, environmentally friendly preservatives that can prolong the shelf life of cereals.

Metabolic Switch in Endocrine Resistant Estrogen Receptor Positive Breast Cancer.

Purpose: The development of endocrine resistance remains a significant challenge in the clinical management of estrogen receptor-positive () breast cancer. Metabolic reprogramming is a prominent component of endocrine resistance and a potential therapeutic intervention point. However, a limited understanding of which metabolic changes are conserved across the heterogeneous landscape of ER+ breast cancer or how metabolic changes factor into ER DNA binding patterns hinder our ability to target metabolic adaptation as a treatment strategy.

Maf1 Cooperates with Progesterone Receptor to Repress RNA Polymerase III Transcription of Select tRNAs.

Progesterone receptors (PR) can regulate transcription by RNA Polymerase III (Pol III), which transcribes small non-coding RNAs, including all transfer RNAs (tRNAs). We have previously demonstrated that PR is associated with the Pol III complex at tRNA genes and that progestins downregulate tRNA transcripts in breast tumor models. To further elucidate the mechanism of PR-mediated regulation of Pol III, we studied the interplay between PR, the Pol III repressor Maf1, and TFIIIB, a core transcription component.

The 2023 fatal dengue outbreak in Bangladesh highlights a paradigm shift of geographical distribution of cases.

In 2023, Bangladesh experienced its largest and deadliest outbreak of the Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. Historically, most of the cases were recorded in the capital city, Dhaka. We aimed to characterize the geographical transmission of DENV in Bangladesh.

Designing structured postgraduate training programs using agile methods.

Postgraduate medical education (PGME) is an essential part of medical education and increasingly shifts into focus of educational stakeholders. Structured postgraduate medical training programs are required in the U.S.

Insight into Stabilization of G-Quadruplex in c-MYC Region with Phenanthroimidazoisoindol-Acrylates and their Binding Behaviour towards Human Serum Albumin.

The interaction of G-quadruplex (non-canonical DNA) with suitable compounds for their stabilization at the promoter region of oncogenes has become a potential anticancer approach. We have studied the interaction of phenanthroimidazoisoindol-acrylates derivatives with c-MYC G-quadruplex. A series of 20 compounds were evaluated for their anticancer activity against human cancer cell lines, where compounds 3 fa, 3 ha, and 3 ae have shown the broad-spectrum anticancer activities against most of the cancer cell lines and inactive towards normal cell lines.

A Complex Case of COVID-19 Pneumonitis in a Patient With Follicular Lymphoma.

Protracted COVID-19 is increasingly recognised in immunocompromised patients, particularly those with haematological malignancies. Here, we present the case of a patient with protracted COVID-19 and an underlying B-cell malignancy. Standard COVID-19 treatment with remdesivir and steroids proved ineffective in this patient as she continued to have evolving ground-glass opacities on imaging.