Publications by authors named "Paul Jack Karanicolas"
Article Synopsis
- Surgical stress can weaken the immune system in patients after surgery, increasing the risk of infections and possibly cancer recurrence; this study examines how dietary changes, specifically arginine-enhanced diets, can improve immune function during and after hepatopancreaticobiliary surgery.
- The study is a randomized controlled trial with 45 patients, aiming to compare immune function and clinical outcomes between a control group and those receiving immunonutrition, measuring changes in natural killer cell activity one day after surgery.
- Ethical approval has been obtained for the trial, and results will be shared through various channels including conferences, publications, and the ClinicalTrials.gov database to ensure transparency and accessibility of information.
Article Synopsis
- A study is looking at how to reduce blood transfusions needed during liver surgery because many patients still need them after surgery, which can be risky.
- Researchers will test a drug called tranexamic acid (TXA) on 1230 people to see if it can help lower blood loss during surgery and reduce the need for transfusions.
- The study is approved by health authorities, and results will be shared to help others learn from the findings.
Objective: Conventional management of pain following open liver resection involves intravenous, patient-controlled analgesia (IV PCA) or epidural analgesia. The objective of this trial was to assess the efficacy of a regional technique called Medial Open Transversus Abdominis Plane (MOTAP) catheter analgesia compared with IV PCA.
Methods: This was a blinded, randomized, controlled parallel-arm trial conducted at 2 high-volume centers.
Purpose: This study measured observer variation in radiographic rating of elbow arthrosis.
Methods: Thirty-seven independent orthopedic surgeons graded the extent of elbow arthrosis in 20 consecutive sets of plain radiographs, according to the Broberg and Morrey rating system (grade 0, normal joint; grade 1, slight joint-space narrowing with minimum osteophyte formation; grade 2, moderate joint-space narrowing with moderate osteophyte formation; and grade 3, severe degenerative change with gross destruction of the joint). The kappa multirater measure (κ) was used to estimate reliability between observers, with 0 indicating no agreement above chance, and 1 indicating perfect agreement.
Purpose: This study tests the hypothesis that 3-dimensional computed tomography (CT) reconstructions improve interobserver agreement on classification and treatment of coronoid fractures compared with 2-dimensional CT.
Methods: A total of 29 orthopedic surgeons evaluated 10 coronoid fractures on 2 occasions (first with radiographs and 2-dimensional CT and then with radiographs and 3-dimensional CT), separated by a minimum of 2 weeks. Surgeons classified fractures according to the classifications of Regan and Morrey and of O'Driscoll et al.
Objective: To assist investigators planning, coordinating, and conducting systematic reviews in the selection of data-extraction tools for conducting systematic reviews.
Study Design And Setting: We constructed an initial table listing available data-collection tools and reflecting our experience with these tools and their performance. An international group of experts iteratively reviewed the table and reflected on the performance of the tools until no new insights and consensus resulted.