A novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to and biofilms.

Introduction: Combined infections from and are a leading cause of death in the developed world. Evidence suggests that enhances the virulence of -hyphae penetrate through tissue barriers, while tightly associates with the hyphae to obtain entry to the host organism. Indeed, in a biofilm state, enhances the antimicrobial resistance characteristics of .

Characterization of iodinated disinfection by-products in chlorinated and chloraminated waters using Orbitrap based gas chromatography-mass spectrometry.

Recent developments in gas chromatography (GC)-mass spectrometry (MS) have opened up the possibility to use the high resolution-accurate mass (HRAM) Orbitrap mass analyzer to further characterize the volatile and semivolatile fractions of environmental samples. This work describes the utilization of GC Orbitrap MS technology to characterize iodine-containing disinfection by-products (iodo-DBPs) in chlorinated and chloraminated DBP mixture concentrates. These DBP mixtures were generated in lab-scale disinfection reactions using Llobregat river water and solutions containing Nordic Lake natural organic matter (NOM).