Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteers.

Background: Rosuvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitor, or statin, that has been developed for the treatment of dyslipidemia.

Objective: This study assessed the metabolism, excretion, and pharmacokinetics of a single oral dose of radiolabeled rosuvastatin ([14C]-rosuvastatin) in healthy volunteers.

Methods: This was a nonrandomized, open-label, single-day trial.