Publications by authors named "Paul Friderich"
Article Synopsis
- A study analyzed 451 historic MRSA isolates from Switzerland, collected between 1965 and 1987, to uncover evolutionary patterns and resistance factors compared to modern MRSA samples and international genomes.
- The researchers found 17 unique sequence types (STs), including five new STs, indicating a mix of both previously known and novel genetic variations.
- The dominant type identified among early isolates was ST247-MRSA-I, showing early MRSA strains were primarily from clonal complex 8, while other complexes began appearing from 1980 onwards, highlighting changes in MRSA diversity over time.
A commercially available automated device (MagNA Pure LC) was adapted for nucleic acid extraction of urogenital specimen for subsequent PCR detection of Chlamydia trachomatis and Neisseria gonorrhoeae in a clinical laboratory. Results were compared to the standard manual extraction procedure and showed excellent correlation, with even slightly increased sensitivity.
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