Optimization of Zr PET Imaging for Improved Multisite Quantification and Lesion Detection Using an Anthropomorphic Phantom.

Our objective was to harmonize multicenter Zr PET imaging for oncology trials and to evaluate lesion detection. Seven PET scanners were evaluated using a custom chest oncology phantom with 9 spheric lesions 7-20 mm in diameter. A 4:1 signal-to-background ratio simulated a patient dose of 92.

Summary of the UPICT Protocol for 18F-FDG PET/CT Imaging in Oncology Clinical Trials.

The Uniform Protocols for Imaging in Clinical Trials (UPICT) (18)F-FDG PET/CT protocol is intended to guide the performance of whole-body FDG PET/CT studies within the context of single- and multiple-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of imaging. The aim is to minimize variability in intra- and intersubject, intra- and interplatform, interexamination, and interinstitutional primary or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area.

Quantitative PET/CT scanner performance characterization based upon the society of nuclear medicine and molecular imaging clinical trials network oncology clinical simulator phantom.

Unlabelled: The Clinical Trials Network (CTN) of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) operates a PET/CT phantom imaging program using the CTN's oncology clinical simulator phantom, designed to validate scanners at sites that wish to participate in oncology clinical trials. Since its inception in 2008, the CTN has collected 406 well-characterized phantom datasets from 237 scanners at 170 imaging sites covering the spectrum of commercially available PET/CT systems. The combined and collated phantom data describe a global profile of quantitative performance and variability of PET/CT data used in both clinical practice and clinical trials.

Amyloid deposition and cognition in older adults: the effects of premorbid intellect.

Although amyloid deposition remains a marker of the development of Alzheimer's disease, results linking amyloid and cognition have been equivocal. Twenty-five community-dwelling non-demented older adults were examined with (18)F-flutemetamol, an amyloid imaging agent, and a cognitive battery, including an estimate of premorbid intellect and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). In the first model, (18)F-flutemetamol uptake significantly correlated with the Delayed Memory Index of the RBANS (r = -.

(18)F-FDG PET in the evaluation of acuity of deep vein thrombosis.

Purpose: F-FDG PET has been used for vascular disease, but its role in deep vein thrombosis (DVT) remains prospectively unexplored.

Patients And Methods: Whole-body F-FDG PET/CT scans were performed in patients 1 to 10 weeks after onset of symptomatic DVT (n = 12) and in control subjects without DVT (n = 24). The metabolic activity (SUVmax) of thrombosed and contralateral nonthrombosed vein segments was determined.

Comparison of 18F-fluorodeoxyglucose and 18F-fluorothymidine PET in differentiating radiation necrosis from recurrent glioma.

Purpose: The objective was to compare F-fluorodeoxyglucose (FDG) and F-fluorothymidine (FLT) PET in differentiating radiation necrosis from recurrent glioma.

Materials And Methods: Visual and quantitative analyses were derived from static FDG PET and static and dynamic FLT PET in 15 patients with suspected recurrence of treated grade 2 glioma or worse with a new focus of Gd contrast enhancement on MRI. For FDG PET, SUVmax and the ratio of lesion SUVmax to the SUVmean of contralateral white matter were measured.

Comparison of whole-body PET/CT, dedicated high-resolution head and neck PET/CT, and contrast-enhanced CT in preoperative staging of clinically M0 squamous cell carcinoma of the head and neck.

Unlabelled: The purpose of this study was to compare optimized whole-body (WB) and dedicated high-resolution contrast-enhanced PET/CT protocols and contrast enhanced CT in the preoperative staging of primary squamous cell carcinoma of the head and neck.

Methods: A total of 44 patients with clinically M0 squamous cell carcinoma of the head and neck underwent primary tumor resection and neck dissection within 6 wk of diagnostic imaging. Imaging consisted of a standard WB PET/CT protocol without intravenous contrast enhancement, followed by a high-resolution dedicated head and neck (HN) PET/CT protocol, which included diagnostic-quality contrast-enhanced CT (CECT).

Measurements of activation products associated with Havar foils from a GE PETtrace medical cyclotron using high resolution gamma spectroscopy.

Havar foils are specially engineered for beam-line windows used in the General Electric (GE) PETtrace medical cyclotron that can withstand the high pressure differentials and also temperatures developed near the target with proton bombardment. These foils effectively separate components along the beam line of the cyclotron. Various activation products are produced in the foils from the primary proton beam and other secondary radiations.

Estimating myocardial perfusion from dynamic contrast-enhanced CMR with a model-independent deconvolution method.

Background: Model-independent analysis with B-spline regularization has been used to quantify myocardial blood flow (perfusion) in dynamic contrast-enhanced cardiovascular magnetic resonance (CMR) studies. However, the model-independent approach has not been extensively evaluated to determine how the contrast-to-noise ratio between blood and tissue enhancement affects estimates of myocardial perfusion and the degree to which the regularization is dependent on the noise in the measured enhancement data. We investigated these questions with a model-independent analysis method that uses iterative minimization and a temporal smoothness regularizer.

Easy method of patient positioning for convergent-beam cardiac SPECT.

Unlabelled: The use of convergent-beam SPECT can increase detection sensitivity; however, the projection data are likely to be truncated if the patient is not properly positioned. This article describes a patient-positioning method that has been adopted in our hospital for cardiac SPECT scans when convergent-beam collimators are used.

Methods: The system that we use has 3 detector heads and a patient table (i.

Position paper on the development of a middle level provider in nuclear medicine: the nuclear medicine practitioner.

The development of an educational program and credentialing structure to support and recognize an advanced level of the practice of nuclear medicine technology is now underway. This work parallels the efforts in many, if not most, health care disciplines as they seek to achieve the twin goals of developing enhanced career paths and providing the best possible patient care in an environment where science and technology can run roughshod over concepts taught in the classroom a mere decade ago. Education is key to both goals.

Comparative evaluation of lesion detectability for 6 PET imaging platforms using a highly reproducible whole-body phantom with (22)Na lesions and localization ROC analysis.

Unlabelled: The lesion detectability performance of 6 PET imaging platforms has been compared using a highly reproducible whole-body phantom and localization receiver operating characteristic (LROC) analysis.

Methods: A realistic whole-body phantom consisting of brain, thorax with lungs and liver, and pelvis with bladder was assembled and outfitted with 27 semipermanent (22)Na lesions of various sizes and activity concentrations. The background compartments were reproducibly filled with (18)F solutions.

Comparison of Static and Dynamic Cardiac Perfusion Thallium-201 SPECT.

Cardiac SPECT is typically performed clinically with static imaging protocols and visually assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic imaging, however, has the potential to provide quantitative measures of flow, possibly improving diagnosis. The objective of this study was to compare the information content of dynamic and static thallium SPECT imaging as measures of myocardial perfusion.