Publications by authors named "Paul Drescher"
Article Synopsis
- Congenital neutropenia leads to low neutrophil counts and increased susceptibility to infections, often requiring lifelong treatment with granulocyte colony-stimulating factor (G-CSF).
- X-linked neutropenia (XLN) is caused by mutations in the Wiskott-Aldrich syndrome protein (WASp), leading to reduced neutrophil production but hyperactive neutrophils that are still present in saliva.
- Research shows that XLN neutrophils exhibit enhanced actin dynamics and tissue migration due to constitutive activation of WASp, allowing them to compensate for the decrease in neutrophil production.
The immune state of wild animals is largely unknown. Knowing this and what affects it is important in understanding how infection and disease affects wild animals. The immune state of wild animals is also important in understanding the biology of their pathogens, which is directly relevant to explaining pathogen spillover among species, including to humans.
View Article and Find Full Text PDFThe laboratory mouse is the workhorse of immunology, used as a model of mammalian immune function, but how well immune responses of laboratory mice reflect those of free-living animals is unknown. Here we comprehensively characterize serological, cellular and functional immune parameters of wild mice and compare them with laboratory mice, finding that wild mouse cellular immune systems are, comparatively, in a highly activated (primed) state. Associations between immune parameters and infection suggest that high level pathogen exposure drives this activation.
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