Publications by authors named "Paul Dennesen"
Article Synopsis
- Some young people under 50 who have a type of brain bleed called aSAH and also have migraines were studied to see if they are more likely to have brain problems later on.
- 236 patients were looked at, and it was found that having a history of migraines did not increase their risk of having further brain issues compared to those without migraines.
- This means that having migraines doesn't seem to make it more likely for these young patients with aSAH to experience serious complications later.
Background And Purpose: Delayed cerebral ischemia (DCI) is a major contributor to the high morbidity in patients with aneurysmal subarachnoid hemorrhage (aSAH). Spreading depolarizations may play a role in DCI pathophysiology. Because patients with migraine are probably more susceptible to spreading depolarizations, we investigated whether patients with aneurysmal subarachnoid hemorrhage with migraine are at increased risk for DCI.
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- The study aimed to assess if haloperidol, given preventively, could enhance survival rates in critically ill adults prone to delirium, involving 1,789 participants across 21 ICUs in the Netherlands.
- The research found no significant difference in survival rates between the haloperidol (both 1 mg and 2 mg) and placebo groups after 28 days, leading to the early termination of the 1-mg haloperidol group due to lack of effectiveness.
- Additionally, 15 secondary outcomes related to delirium and ICU stay showed no noteworthy differences, indicating that prophylactic haloperidol might not be beneficial for this patient population.
Article Synopsis
- Scientists are creating automated systems to make it easier and more reliable to find infections in hospitals, instead of doing it by hand.
- This study tested a special prediction model against traditional methods for spotting a specific infection in patients who had surgery on their brains.
- The new model was very effective, needing less manual checking and able to identify high-risk patients with great accuracy, which helps doctors do their job more easily.
Article Synopsis
- Nurses and physicians in intensive care showed increased expectations for the effectiveness of selective decontamination of the digestive tract (SDD) as a study progressed.
- Despite this, both SDD and selective oropharyngeal decontamination (SOD) were seen as raising workload and being less patient-friendly compared to standard care.
- The study highlights the need for better education regarding oral care and the impact of SDD and SOD on patient outcomes.
In patients with aneurysmal subarachnoid hemorrhage (SAH), secondary complications are an important cause of morbidity and case fatality. Delayed cerebral ischemia and hydrocephalus are important intracranial secondary complications. Potentially treatable extracranial complications are also frequently observed, and some are related to the occurrence of delayed cerebral ischemia and outcome.
View Article and Find Full Text PDFObjective: Current prognosticators for patients with subarachnoid hemorrhage (SAH) do not take into account signs of extracerebral organ dysfunction. This may explain the only moderate predictive value of these prognosticators. We assessed the prognostic value of the simplified acute physiology score (SAPS) II in SAH patients.
View Article and Find Full Text PDFObjective: To compare the levels of sulfated mucins in bronchoalveolar lavage fluid (BALF) in ICU patients with ventilator-associated pneumonia (VAP) with those in non-infectious controls, i.e., ventilated ICU patients without VAP, and nonventilated patients.
View Article and Find Full Text PDFObjective: To investigate salivary flow and frequency of oral mucositis in intensive care unit patients compared with patients admitted because of elective coronary artery bypass graft (CABG) surgery. In addition, the pattern of oropharyngeal colonization was investigated in these patients.
Design: Prospective study.