A Randomized Trial of Ketorolac vs. Sumatripan vs. Placebo Nasal Spray (KSPN) for Acute Migraine.

Objective: To compare the efficacy of ketorolac nasal spray (NS) vs. placebo and sumatriptan NS for the acute treatment of migraine.

Methods: This was a randomized, double-blind, placebo and active-comparator, crossover study.

Ictal adipokines are associated with pain severity and treatment response in episodic migraine.

Objective: To evaluate ictal adipokine levels in episodic migraineurs and their association with pain severity and treatment response.

Methods: This was a double-blind, placebo-controlled trial evaluating peripheral blood specimens from episodic migraineurs at acute pain onset and 30 to 120 minutes after treatment with sumatriptan/naproxen sodium vs placebo. Total adiponectin (T-ADP), ADP multimers (high molecular weight [HMW], middle molecular weight, and low molecular weight [LMW]), leptin, and resistin levels were evaluated by immunoassays.

Ictal adiponectin levels in episodic migraineurs: a randomized pilot trial.

Objective: To assess ictal adiponectin (ADP) levels before and after acute abortive treatment in women episodic migraineurs.

Methods: Peripheral blood specimens were collected from women episodic migraineurs before and after acute abortive treatment with sumatriptan/naproxen sodium vs placebo. Univariate and multivariate models were utilized to examine the relationship between serum total ADP (T-ADP), ADP oligomers (high molecular weight [HMW], middle molecular weight, and low molecular weight [LMW]-ADP), and ADP ratio levels and pain severity.