The mesoanatomy of the cortex, minimization of free energy, and generative cognition.

Capacity for generativity and unlimited association is the defining characteristic of sentience, and this capacity somehow arises from neuronal self-organization in the cortex. We have previously argued that, consistent with the free energy principle, cortical development is driven by synaptic and cellular selection maximizing synchrony, with effects manifesting in a wide range of features of mesoscopic cortical anatomy. Here, we further argue that in the postnatal stage, as more structured inputs reach the cortex, the same principles of self-organization continue to operate at multitudes of local cortical sites.

Unification of free energy minimization, spatiotemporal energy, and dimension reduction models of V1 organization: Postnatal learning on an antenatal scaffold.

Developmental selection of neurons and synapses so as to maximize pulse synchrony has recently been used to explain antenatal cortical development. Consequences of the same selection process-an application of the Free Energy Principle-are here followed into the postnatal phase in V1, and the implications for cognitive function are considered. Structured inputs transformed lag relay in superficial patch connections lead to the generation of circumferential synaptic connectivity superimposed upon the antenatal, radial, "like-to-like" connectivity surrounding each singularity.

Different visual stimuli affect muscle activation at the knee during sidestepping.

Increasing knee stability via appropriate muscle activation could reduce anterior cruciate ligament (ACL) injury risk during unplanned sidestepping. High-level athletes may activate their knee muscles differently from low-level athletes when responding to quasi-game realistic versus non game-realistic stimuli. Eleven high-level and 10 low-level soccer players responded to a non game-realistic arrow-planned condition (AP), a quasi game-realistic one-defender scenario (1DS) and two-defender scenario (2DS), and an arrow-unplanned condition (AUNP), that imposed increasing time constraints to sidestep.

Further Work on the Shaping of Cortical Development and Function by Synchrony and Metabolic Competition.

This paper furthers our attempts to resolve two major controversies-whether gamma synchrony plays a role in cognition, and whether cortical columns are functionally important. We have previously argued that the configuration of cortical cells that emerges in development is that which maximizes the magnitude of synchronous oscillation and minimizes metabolic cost. Here we analyze the separate effects in development of minimization of axonal lengths, and of early Hebbian learning and selective distribution of resources to growing synapses, by showing in simulations that these effects are partially antagonistic, but their interaction during development produces accurate anatomical and functional properties for both columnar and non-columnar cortex.

Möbius-strip-like columnar functional connections are revealed in somato-sensory receptive field centroids.

Receptive fields of neurons in the forelimb region of areas 3b and 1 of primary somatosensory cortex, in cats and monkeys, were mapped using extracellular recordings obtained sequentially from nearly radial penetrations. Locations of the field centroids indicated the presence of a functional system in which cortical homotypic representations of the limb surfaces are entwined in three-dimensional Möbius-strip-like patterns of synaptic connections. Boundaries of somatosensory receptive field in nested groups irregularly overlie the centroid order, and are interpreted as arising from the superposition of learned connections upon the embryonic order.

On the dynamics of cortical development: synchrony and synaptic self-organization.

We describe a model for cortical development that resolves long-standing difficulties of earlier models. It is proposed that, during embryonic development, synchronous firing of neurons and their competition for limited metabolic resources leads to selection of an array of neurons with ultra-small-world characteristics. Consequently, in the visual cortex, macrocolumns linked by superficial patchy connections emerge in anatomically realistic patterns, with an ante-natal arrangement which projects signals from the surrounding cortex onto each macrocolumn in a form analogous to the projection of a Euclidean plane onto a Möbius strip.

Visual search differs but not reaction time when intercepting a 3D versus 2D videoed opponent.

The authors aimed to identify differences in (a) visual search and (b) reaction time when athletes sidestepped to intercept 2D versus 3D videoed opponents. They hypothesized that participants would (a) fixate on different parts of the opponent's body and (b) react quicker when responding to the 3D versus 2D opponent due to the added depth cues. A customized integrated stereoscopic system projected the video stimuli and synchronously recorded the gaze and motor behaviors of 10 men when they responded to two- (2D) and three-dimensional (3D) opponents.

Effects of different visual stimuli on postures and knee moments during sidestepping.

Purpose: Evasive sidestepping during sports commonly results in noncontact anterior cruciate ligament injuries. Sidestepping in response to different simple visual stimuli has been studied previously but never investigated using quasi-game-realistic visual conditions. We compared the biomechanics of high-level and low-level soccer players when sidestepping in response to projected, three-dimensional defender(s) and the traditionally used planned and unplanned arrow stimuli.

Intrinsic connections in tree shrew V1 imply a global to local mapping.

The local-global map hypothesis states that locally organized response properties--such as orientation preference--result from visuotopically organized local maps of non-retinotopic response properties. In the tree shrew, the lateral extent of horizontal patchy connections is as much as 80-100% of V1 and is consistent with the length summation property. We argue that neural signals can be transmitted across the entire extent of V1 and this allows the formation of maps at the local scale that are visuotopically organized.

Spatial eigenmodes and synchronous oscillation: co-incidence detection in simulated cerebral cortex.

Zero-lag synchronisation arises between points on the cerebral cortex receiving concurrent independent inputs; an observation generally ascribed to nonlinear mechanisms. Using simulations of cerebral cortex and Principal Component Analysis (PCA) we show patterns of zero-lag synchronisation (associated with empirically realistic spectral content) can arise from both linear and nonlinear mechanisms. For low levels of activation, we show the synchronous field is described by the eigenmodes of the resultant damped wave activity.