Coronal tibiofemoral subluxation is not an independent risk factor for total knee arthroplasty in patients with moderate to severe varus-osteoarthritis: data from the "Osteoarthritis Initiative".

Purpose: Only few prognostic factors for progression of knee osteoarthritis are well established, including varus malalignment. The purpose of this study was to evaluate whether coronal tibiofemoral subluxation is a predictor for total knee arthroplasty.

Methods: Patients from the progression subcohort of the longitudinal database "Osteoarthritis Initiative" with moderate to severe osteoarthritis and varus malalignment of greater than 3 degrees were included.

Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance.

Objective: It was hypothesized that resistin links obesity with diabetes, but this has not been studied in children and adolescents to date.

Patients: We determined serum resistin levels of 135 obese (body mass index, 32.0 +/- 6.