Publications by authors named "Paul B Rice"
J Gen Virol
November 2013
Article Synopsis
- Development of transgenic mouse models with a chimeric murine/ovine prion protein (PrP) allows researchers to study the susceptibility of these mice to ruminant prion diseases.
- The newly created Tg(Mu/OvPrP(AHQ))EM16 mice show high susceptibility to various prions, achieving 100% disease penetrance and rapid disease progression compared to wild-type mice.
- The study confirms that these EM16 mice are effective for differentiating ruminant prions and detecting atypical scrapie infectivity through various diagnostic methods.
