Publications by Paul A Mieyal

Publications by authors named "Paul A Mieyal"

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Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.

Nader G Abraham Shuo Quan Paul A Mieyal Liming Yang Theresa Burke-Wolin

Am J Physiol Lung Cell Mol Physiol

November 2002

Carbon monoxide (CO) stimulates guanylate cyclase (GC) and increases guanosine 3',5'-cyclic monophosphate (cGMP) levels. We transfected rat-lung pulmonary endothelial cells with a retrovirus-mediated human heme oxygenase (hHO)-1 gene. Pulmonary cells that expressed hHO-1 exhibited a fourfold increase in HO activity associated with decreases in the steady-state levels of heme and cGMP without changes in soluble GC (sGC) and endothelial nitric oxide synthase (NOS) proteins or basal nitrite production.

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- Research by Paul A. Mieyal focuses on the modulation of signaling pathways related to heme oxygenase-1 (HO-1) and its effects on endothelial cell function, particularly in pulmonary microvessels.
- One key study investigated how gene transfer of human HO-1 via retroviral methods can significantly alter levels of carbon monoxide (CO) and guanosine 3',5'-cyclic monophosphate (cGMP) in rat-lung pulmonary endothelial cells.
- Findings indicate that while HO-1 expression increases HO activity, it concurrently leads to decreases in both heme and cGMP levels without affecting the expression of soluble guanylate cyclase or endothelial nitric oxide synthase proteins, highlighting a complex regulatory pathway.

Publications by authors named "Paul A Mieyal"

Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.

Synopsis of recent research by authors named "Paul A Mieyal"