Publications by authors named "Paul A Lacy"
Bovine babesiosis is a vector-borne disease transmitted by ticks that causes important losses in livestock worldwide. Recent research performed on the drugs currently used to control bovine babesiosis reported several issues including drug resistance, toxicity impact, and residues in edible tissue, suggesting the need for developing novel effective therapies. The endochin-like quinolones ELQ-316 and buparvaquone (BPQ) act as cytochrome 1 inhibitors and have been proven to be safe and efficacious against related apicomplexans, such as spp.
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- Bovine babesiosis, a disease caused by a parasite carried by ticks, poses a global threat to cattle, highlighting the need for new vaccines.
- Researchers identified immune-subdominant (ISD) antigens, specifically rRAP-1 NT and rRRA, which elicited lower antibody responses compared to dominant antigens in previously protected cattle.
- Vaccination of cattle with rRRA and rRAP-1 NT showed promising results, as most immunized animals developed strong immune responses and experienced a delay in sickness symptoms when exposed to the parasite, indicating the potential for these ISD antigens in developing future vaccines.
Article Synopsis
- Bovine babesiosis is a tick-borne disease caused by an apicomplexan parasite, and treatment options like imidocarb dipropionate (ID) are currently limited and ineffective, prompting research into the efficacy of buparvaquone (BPQ).
- In controlled laboratory tests, both BPQ and ID significantly inhibited parasite growth, with BPQ showing a lower inhibitory concentration (IC50) than ID, indicating it may be more effective at various levels of infection.
- The study concludes that BPQ not only effectively combats the parasite but also exhibits a longer-lasting effect compared to ID, potentially making it a better option for treating bovine babesiosis.
Introduction: , a tick-borne apicomplexan parasite causing bovine babesiosis, remains a significant threat worldwide, and improved and practical vaccines are needed. Previous studies defined the members of the rhoptry associated protein-1 (RAP-1), and the neutralization-sensitive rhoptry associated protein-1 related antigen (RRA) superfamily in , as strong candidates for the development of subunit vaccines. Both RAP-1 and RRA share conservation of a group of 4 cysteines and amino acids motifs at the amino terminal end (NT) of these proteins.
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