"Every Cloud Has a Silver Lining": How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It.

The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman's and Bartter's Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.

Balancing Time for Health Behaviors: Associations of Time Perspective With Physical Activity and Weight Management in Older Adults.

Purpose: To examine associations between time perspective and health promotion behaviors of physical activity and weight management.

Design: Quantitative cross-sectional.

Setting: This study is part of the Betula project on aging, memory, and dementia in Northern Sweden.

Oxidants and Cardiorenal Vascular Remodeling-Insights from Rare Genetic Tubulopathies: Bartter's and Gitelman's Syndromes.

Two human genetic tubulopathies, Bartter's (BS) and Gitelman's (GS) syndromes, have normo/hypotension and absent cardiac remodeling despite their apparent angiotensin system (RAS) activation. This seeming contradiction has led to an extensive investigation of BSGS patients, the result of which is that BSGS represents a mirror image of hypertension. BSGS's unique set of properties has then permitted their use as a human model to probe and characterize RAS system pathways and oxidative stress in cardiovascular and renal remodeling and pathophysiology.

Preliminary Psychometric Validation of the Teammate Burnout Questionnaire.

The aim of the present study was to provide support for the validation of the Teammate Burnout Questionnaire (TBQ). Athletes from a variety of team sports ( = 290) completed the TBQ and the Athlete Burnout Questionnaire (ABQ). Confirmatory factor analysis revealed acceptable fit indexes for the three-dimensional models (i.

The psychophysiological influence of exertion and affect on sport-specific cognitive and physical performance.

Objectives: The purpose of the present study was to examine differences in cognitive and physical performance, affective states, perceived exertion, and physiological responses between trials with cognitive, physical, or combined cognitive and physical load.

Design: Randomised cross-over trial.

Methods: Highly trained competitive orienteers (n = 15 men; n = 10 women) completed three randomised trials comprised of: (1) sport-specific cognitive tests; (2) 35-minute cycling time trial; and (3) combined sport-specific cognitive tests and 35-minute cycling time trial.

Examining the Impact of School Esports Program Participation on Student Health and Psychological Development.

This study examined the influence of 7 high school esports developmental programs on student self-regulation, growth mindset, positive youth development (PYD), perceived general health and physical activity (PA), and sport behaviour. A total of 188 students (male = 120; female = 68) originally participated (89 enrolled in an esports program in their school and 99 acted as aged-matched controls), with 58 participants ( = 19 esports group; = 39 controls) completing both pre- and post-program information. At baseline, no significant differences were found between youth e-athletes and their aged-matched controls.

Social Support, Self-Regulation, and Psychological Skill Use in E-Athletes.

The aims of the present study were twofold. First, to investigate self-reported social support, self-regulation, and psychological skill use in esports athletes (e-athletes) compared to traditional athletes. Second, to determine if self-reported social support, self-regulation, and psychological skill use influenced e-athlete in-game rank.

Tracing angiotensin II's yin-yang effects on cardiovascular-renal pathophysiology.

Adverse changes in cardiovascular and renal systems are major contributors to overall morbidity and mortality. Human cardiovascular and renal systems exhibit a complex network of positive and negative feedback that is reflected in the control of vascular tone via angiotensin II (Ang II) based signaling. This review will examine in some depth, the multiple components and processes that control the status and reflect the health of these various cardiovascular and renal systems, such as pathways associated to monomeric G proteins, RhoA/Rho kinase system and ERK, oxidative stress and NO balance.

Recall of Affective Responses to Exercise: Examining the Influence of Intensity and Time.

Affective responses to exercise are noted to be dynamic and frequently vacillate between positive and negative valence during physical activity. Recalled affect following exercise can influence anticipated affective responses to exercise and guide future behaviors. Research examining affective memory processes indicates that the recall of an experience can substantially differ from the actual experience and change over time.

Written Emotional Disclosure Can Promote Athletes' Mental Health and Performance Readiness During the COVID-19 Pandemic.

The widespread effects of the coronavirus disease 2019 (COVID-19) pandemic have negatively impacted upon many athletes' mental health and increased reports of depression as well as symptoms of anxiety. Disruptions to training and competition schedules can induce athletes' emotional distress, while concomitant government-imposed restrictions (e.g.

Integrating yoga with psychological group-treatment for mixed depression and anxiety in primary healthcare: An explorative pilot study.

Background And Purpose: Yoga has shown promise as a treatment for depression and anxiety. The present pilot study investigated the feasibility of an eight-week grouptreatment integrating emotion-focused psychoeducation, compassion-focused therapy, and Virya yoga for depression and anxiety in primary healthcare.

Materials And Methods: Patients seeking treatment for depression and anxiety in a primary healthcare centre completed either an integrative group-treatment (N = 14) or treatment as usual (TAU, N = 17).

The Association between Esports Participation, Health and Physical Activity Behaviour.

We investigated the association between obesity, self-reported physical activity, cigarette smoking, alcohol consumption, and perceived health in esports players, and the influence of player in-game rank. Data was collected with an online survey with an international participant sample of esports players representing five esports and all skill levels ( = 1772). Esports players were more likely to be categorized as normal weight, or obesity class 2 and 3 and as non-smokers (92%) and non-drinkers (65.

Are the Clinical Presentations (Phenotypes) of Gitelman's and Bartter's Syndromes Gene Mutations Driven by Their Effects on Intracellular pH, Their "pH" Enotype?

Gitelman's syndrome (GS) and Bartter's syndrome (BS) are rare inherited salt-losing tubulopathies whose variations in genotype do not correlate well with either clinical course or electrolyte requirements. Using GS/BS patients as nature's experiments, we found them to be a human model of endogenous Ang II antagonism with activated Renin-Angiotensin System (RAS), resulting in high Ang II levels with blunted cardiovascular effects. These patients are also characterized by increased and directly correlated levels of both Angiotensin Converting Enzyme 2 (ACE2) and Ang 1-7.

Temporal aspects of affective states, physiological responses, and perceived exertion in competitive cycling time trials.

Athletes' affective states can vary dramatically before, during, and after competition. Further, intense affect is associated with physiological responses that may amplify biological reactions manifested from the execution of physical tasks underlying performance. Fluctuations in perceptual cues (eg, perceived exertion) and physiological responses (eg, blood lactate, heart rate) can influence performance and vary dramatically in relation to competition.