Expanded carrier screening in an infertile population: how often is clinical decision making affected?

Purpose: Options for preconception genetic screening have grown dramatically. Expanded carrier screening (ECS) now allows for determining carrier status for hundreds of genetic mutations by using a single sample, and some recommend ECS prior to in vitro fertilization. This study seeks to evaluate how often ECS alters clinical management when patients present for infertility care.

Evidence-Based Care for Couples With Infertility.

When couples cannot achieve pregnancy, they often seek health care from medical and nursing specialists. The care the couple receives begins with a thorough assessment to determine the possible cause of infertility and to plan appropriate care to ensure the best chance for the couple to have a biological child. In this article, we provide an overview of the etiology and evaluation of infertility, the various treatment options available, and the appropriate clinical implications.

Endometrial disruption does not improve implantation in patients who have failed the transfer of euploid blastocysts.

Purpose: To assess the impact of single pass outpatient endometrial biopsy in patients at the highest risk for an endometrial cause for failed implantation; those that have failed to conceive despite the transfer of morphologically normal euploid embryos.

Methods: This is a retrospective cohort study consisting of all patients less than 42 years old who failed their first euploid blastocyst transfer and subsequently completed a second transfer cycle of euploid blastocysts. Cycles were analyzed to determine if a single pass endometrial biopsy, termed 'endometrial disruption', was performed in a cycle preceding their second embryo transfer.

Use of single nucleotide polymorphism microarrays to distinguish between balanced and normal chromosomes in embryos from a translocation carrier.

Objective: To prove the ability to distinguish between balanced and normal chromosomes in embryos from a translocation carrier.

Design: Case report.

Setting: Academic center for reproductive medicine.

Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: an analysis of 6021 pregnancies.

Objective: To correlate the live delivery rate with the initial level and rise of serum beta-hCG.

Design: Retrospective cohort analysis.

Setting: Large private academic center for assisted reproductive technologies and infertility.

A luteal estradiol protocol for expected poor-responders improves embryo number and quality.

Objective: To compare embryo and oocyte data between a standard protocol and a luteal phase estradiol protocol.

Design: Retrospective paired cohort analysis.

Setting: Private in vitro fertilization (IVF) center.

Embryonic synergism may reduce pregnancy loss: a multivariate regression analysis.

Objective: To evaluate clinical and assisted reproductive technology (ART) cycle variables related to spontaneous embryo reduction.

Design: Observational retrospective cohort study.

Setting: Private ART center.