Publications by authors named "Pau Llacer-Iborra"
Background And Aims: Acute heart failure (AHF) promotes inflammatory activation, which is associated with worse outcomes. Colchicine has proven effective in other cardiovascular conditions characterized by inflammatory activation, but has never been evaluated in the setting of AHF.
Methods: This multicenter, randomized, double-blind and placebo-controlled trial included patients with AHF, requiring ≥40 mg of intravenous furosemide, regardless of their left ventricular ejection fraction (LVEF) and inpatient or outpatient setting.
Aims: Heart failure (HF) elicits a pro-inflammatory state, which is associated with impaired clinical outcomes, but no anti-inflammatory therapies have demonstrated a clinical benefit yet. Inflammatory pathways related with the interleukin-1 axis are overactivated during episodes of acute HF. Colchicine, an anti-inflammatory drug with proven benefits in acute pericarditis and ischaemic heart disease, may target this inflammatory response.
View Article and Find Full Text PDFThe Effects of a Therapeutic Strategy Guided by Lung Ultrasound on 6-Month Outcomes in Patients with Heart Failure: Results from the EPICC Randomized Controlled Trial.
J Clin Med
August 2022
Article Synopsis
- A study was conducted to see if lung ultrasound (LUS) could improve treatment outcomes for heart failure patients by detecting pulmonary congestion (PC).
- Patients who had been hospitalized for heart failure were divided into two groups: one received treatment guided by LUS signs of congestion, while the other received standard care.
- Results indicated no significant difference in 6-month outcomes, such as readmissions or emergency visits, between the LUS group and the standard care group, suggesting LUS-guided therapy may not provide additional benefits.
Article Synopsis
- Heart failure (HF) is common in older adults and often worsened by other health issues; this study analyzed data from a national registry of HF patients aged 50 and over.
- Out of 5424 patients, a significant 61% died within a year, with mortality rates increasing as the PROFUND index score (a measure of health risk) rose; those with scores above 11 had the highest risk.
- The findings suggest that the PROFUND index is effective in predicting one-year mortality for HF patients, particularly beneficial for identifying those at intermediate to high risk.
Introduction And Objectives: There is great interest in better characterizing patients with heart failure (HF) with preserved ejection fraction (HF-PEF). The objective of this study is to determine the prevalence, progression over time and to describe the clinical and epidemiological characteristics of patients with HF-PEF.
Methods: From the National Registry of Heart Failure (RICA, prospective multicentre cohort study) we analysed patients consecutively admitted for HF in Internal Medicine wards over a period of 11 years (2008-2018).
Introduction: Acute heart failure (AHF) is a frequent epidemic in geriatrics. The main aim of this study was to evaluate the clinical and prognostic differences of very elderly patients with AHF compared to the rest, and evaluate the factors associated with 90-day mortality.
Methods: We analyzed 3828 patients hospitalized for AHF with an age of ≥ 70 years.
Aim: To improve the knowledge on characteristics, treatment and prognosis in patients with heart failure (HF) and mid-range ejection fraction discharged after an acute HF episode.
Methods: We prospectively included and followed 2753 patients admitted with HF to Internal Medicine units. Patients were classified according to ejection fraction (EF) into three strata: reduced, EF <40% (HFrEF); mid-range EF 40-49% (HFmrEF); and preserved EF ≥50% (HFpEF).
Objectives: Heart rate (HR) and systolic blood pressure (SBP) are independent prognostic variables in patients with heart failure (HF). We evaluated if combining HR and SBP could improve prognostic assessment in older patients.
Methods: Variables associated with all-cause mortality and readmission for HF during 9months of follow-up were analyzed from the Spanish Heart Failure Registry (RICA).