Publications by authors named "Patty Routh"
Adherence of pathogens to cellular targets is required to initiate most infections. Defining strategies that interfere with adhesion is therefore important for the development of preventative measures against infectious diseases. As an adhesin to host extracellular matrix proteins and human keratinocytes, the trimeric autotransporter adhesin DsrA, a proven virulence factor of the Gram-negative bacterium Haemophilus ducreyi, is a potential target for vaccine development.
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- Haemophilus ducreyi requires heme from human hosts for infection, utilizing TonB-dependent transporters, with HgbA being essential for early infection stages.
- Active immunization with the HgbA protein provides complete protection in pig models of chancroid, indicating its potential as a vaccine.
- Passive immunization using anti-nHgbA serum offers some protection against related strains, showing that antibodies can block heme acquisition but do not kill the bacteria directly.
The etiologic agent of chancroid is Haemophilus ducreyi. To fulfill its obligate requirement for heme, H. ducreyi uses two TonB-dependent receptors: the hemoglobin receptor (HgbA) and a receptor for free heme (TdhA).
View Article and Find Full Text PDFAngiogenesis is an essential process during follicular development and corpora lutea (CL) formation. Recent studies have shown that vascular endothelial growth factor (VEGF) is an essential regulator of ovarian angiogenesis. Several lines of evidence have indicated that the production of VEGF is regulated by hypoxia inducible factor-1alpha (HIF-1alpha), especially under hypoxic conditions, but the expression of HIF-1alpha has not been well characterized in the porcine ovary.
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