Potential of Nanoparticle Based Antimicrobial Drug Repurposing to Efficiently Target Alzheimer's: A Concise Update on Evidence-based Research and Challenges Ahead.

Repurposing of drugs through nanocarriers (NCs) based platforms has been a recent trend in drug delivery research. Various routine drugs are now being repurposed to treat challenging neurodegenerative disorders including Alzheimer disease (AD). AD, at present is one of the challenging neurodegenerative disorders characterized by extracellular accumulation of amyloid-β and intracellular accumulations of neurofibrillary tangles.

The interplay of heart rate variability and ventricular repolarization parameters in the obese state: a review.

The impact of obesity on heart rate variability (HRV) and ventricular repolarization, both vital indicators of cardiovascular health, is the focus of this review. Obesity, measured by BMI, waist circumference, and waist-to-hip ratio, significantly increases cardiovascular disease (CVD) risk due to structural and autonomic heart changes. Findings show that obese individuals exhibit prolonged QT and Tpeak-to-Tend (Tpe) intervals, suggesting delayed ventricular recovery and greater arrhythmia risk.

Morpho-biochemical and molecular profiling for Charcoal Rot (CR) disease resistance in Mung Bean [Vigna radiata (L.) Wilczek] landraces.

Background: Charcoal Rot (CR) poses a significant threat to mung bean crops by reducing yield, making the development of resistant varieties crucial for stable production and food security. This study evaluated 19 newly identified mung bean landraces using biochemical traits and SSR markers, revealing genetic variability, CR disease reactions, and traits influencing yield and resistance, which provide valuable insights for breeding CR-resistant, high-yielding varieties.

Methods And Results: Mung bean landraces were evaluated for their response to CR using 4 biochemical parameters, and 10 SSR markers to assess genetic variability and disease resistance.

Homeotic transformation of tail to limbs: A novel morphogenesis in the framework of self-organization and reprogramming of cell fate during appendage regeneration.

Homeotic transformation of tail to hindlimbs in anuran tadpoles is a manifestation of the reprogramming of positional information in the event of tail regeneration. Such discovery of homeosis is of particular interest considering its occurrence in a vertebrate under the influence of a morphogen which represents a self-organizing system in the context of developmental and regenerative studies. This article reviews homeotic transformation of tail to hindlimbs including pelvic girdles induced by retinoic acid (RA) /vitamin A palmitate during tail regeneration under the scope of self-organization and the role of blastema as an organizer.

Correction of Impacted Maxillary Permanent Anteriors - A Case Report.

The maxillary anteriors play the most prominent role in an individual's aesthetics, speech, and majorly psychology. The impaction of maxillary anterior teeth can be a challenging orthodontic problem that can be managed by interceptive orthodontics in early mixed dentition. In this particular case report, interceptive orthodontics alone may not bring desirable results because two problems need to be dealt simultaneously, namely, intraosseous crowding and midline shift due to impaction on the affected quadrant.

Lipid nanocarrier-based bigel of oil for analgesic and anti-inflammatory applications.

Present study reports analgesic and anti-inflammatory potential of (L.) leaf oil loaded lipid nanocarrier (BLNs)-embedded bigel. BLNs were developed by solvent evaporation technique and were characterised by FESEM, Cryo-TEM, mean diameter, zeta potential, loading efficiency, etc.

A timely update on g-CN-based photocatalysts towards the remediation of Cr(vi) in aqueous streams.

Hexavalent chromium (Cr(vi)) is a prominent carcinogen. In environmental engineering, the elimination of hexavalent chromium from aqueous media is a noteworthy field of study. In this regard, nanoparticle science and technology have contributed significantly to the photocatalytic reduction of Cr(vi).

Corrigendum: Prevalence, pattern, and determinants of disabilities in India: Insights from NFHS-5 (2019-21).

[This corrects the article DOI: 10.3389/fpubh.2023.

A prospective cohort study: promising results with minimally invasive plate osteosynthesis of anterior bridge plating in adult humeral shaft fractures.

Background: Adult humeral shaft fractures have traditionally been managed conservatively, but surgical intervention is considered for displaced fractures or when conservative treatment is unlikely to be successful. The optimal surgical approach remains controversial, with open reduction and internal fixation (ORIF) using plates and screws considered the gold standard. However, concerns about soft tissue damage have led to the development of less invasive techniques, such as anterior bridge plating using minimally invasive plate osteosynthesis (MIPO).

Antioxidant, antibacterial and antibiofilm activities of (DC.) against drug-resistant and sp.

Gandhamardan has a rich heritage of floristic diversity with undocumented medicinal plants, called Anukta Dravya having immense pharmacological values. Among them, (DC.) Rehder & E.

Fabrication and characterization of natural fiber reinforced cowpea resin-based green composites: an approach towards agro-waste valorization.

A paradigm shift towards using bio-resins or bio-derived resins among materials scientists has led to wide exploration of the sector. Polymers such as soy protein isolate, poly(hydroxy alkanoate), poly(lactic acid), and thermoplastic starch are all synthetically modified bio-based resins and are costly. The cowpea-derived resin with the least chemical modification was used in this study as a matrix for the formation of composites with natural fibers at a lesser cost.

Is there any concern of insulin resistance and metabolic dysfunctions with antiseizure medications? A prospective comparative study of valproate vs. levetiracetam.

Purpose: To evaluate the incidence of insulin resistance and its association with change in serum anti-seizure medication (ASM) level and their pharmacokinetic, body composition and metabolic hormones after six months of levetiracetam (LEV) exposure in persons with epilepsy (PWE) in comparison to valproate (VPA).

Methods: This prospective-longitudinal study included clinically diagnosed PWE on VPA or LEV monotherapy (for<3 months). At enrolment, body weight/composition, BMI were measured and blood samples were collected for assessing metabolic dysfunctions by estimation of serum insulin, insulin resistance [in terms of Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)], leptin, adiponectin, lipid profile along with ASMs level.

Prevalence of Second Hand Smoke Exposure and Measures to Overcome: A Cross Sectional Study among Youth in Urban Hyderabad.

In India, the prevalence of secondhand smoke (SHS) exposure is 29.5% in general and 11.2% at home.

Telmisartan loaded lipid nanocarrier as a potential repurposing approach to treat glioma: characterization, apoptosis evaluation in U87MG cells, pharmacokinetic and molecular simulation study.

The study explores anticancer potential of telmisartan (TS) loaded lipid nanocarriers (TLNs) in glioma cells as a potential repurposing nanomodality along with estimation of drug availability at rat brain. Experimental TLNs were produced by previously reported method and characterized.anticancer efficacy of experimental TLNs was estimated by MTT, confocal microscopy, and FACs analysis in glioma cells.

Encapsulation of Alpinia leaf essential oil in nanophytosome-embedded gel as novel strategy to treat periodontal infections: evaluation of antimicrobial effectiveness, pharmacokinetic, in vitro-ex vivo correlation and in silico studies.

Aim: The work reports a novel nanophytosomal gel encapsulating (L.) Willd leaf essential oil to treat periodontal infections.

Methods: Alpinia oil-loaded nanophytosomes (ANPs) were formulated by lipid layer hydration technique and were evaluated by FESEM, cryo-TEM, loading efficiency, zeta potential, particle size, release profile etc.

N-MYC impairs innate immune signaling in high-grade serous ovarian carcinoma.

High-grade serous ovarian cancer (HGSC) is a challenging disease, especially for patients with immunologically "cold" tumors devoid of tumor-infiltrating lymphocytes (TILs). We found that HGSC exhibits among the highest levels of expression and transcriptional signature across human cancers, which is strongly linked to diminished features of antitumor immunity. N-MYC repressed basal and induced IFN type I signaling in HGSC cell lines, leading to decreased chemokine expression and T cell chemoattraction.

Physical fitness in Indian women with epilepsy on anti-seizure medications and its association with reproductive status, quality of life and stigma: A cross-sectional study.

Purpose: To determine the status of physical fitness, reproductive abnormalities, QOL and epilepsy associated stigma in women with epilepsy (WWE) and their association with ASM therapy and seizure frequency.

Methods: This cross-sectional study included WWE of reproductive age (18-50 years) on antiseizure medications (ASMs) for at least three months before enrolment. Physical fitness was assessed using International Physical Activity Questionnaires (IPAQ) and Body composition analysis.

A cross-sectional study on adherence to treatment and life-style modifications in hypertensive patients attending the urban health centre of a teaching hospital in Hyderabad.

Introduction: The burden of hypertension is expected to double by 2025 and adherence to treatment has a key role in disease outcome. The World Health Organization defines adherence as the extent to which a person's behaviour of taking medication, following a diet and/or exceeding life-style changes, corresponds with the agreed recommendations of health care providers. The study tries to assess the level of adherence to medication and life-style modifications in hypertensive patients.