Publications by authors named "Patti Lou Cheatley"
Article Synopsis
- - Neutralizing antibodies (Abs) against SARS-CoV-2 vary widely among individuals recovering from the virus, with higher levels found in those with severe COVID-19 cases.
- - Heat inactivation of convalescent serum significantly reduces its neutralization activity by inactivating complement proteins, which play a major role in the body’s immune response against the virus.
- - The study highlights that the complement pathway is crucial for effective viral neutralization and that its contribution can be more than 50% of the neutralizing effect in untreated serum.
Cell-mediated immunity is critical for long-term protection against most viral infections, including coronaviruses. We studied 23 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected survivors over a 1-year post-symptom onset (PSO) interval by cytokine enzyme-linked immunosorbent spot assay (ELISpot) assay. All subjects demonstrated SARS-CoV-2-specific gamma interferon (IFN-γ), interleukin 2 (IL-2), and granzyme B (GzmB) T cell responses at presentation, with greater frequencies in severe disease.
View Article and Find Full Text PDFBackground: Blood group incompatibility (ABOi) is the most common barrier to living donor kidney transplantation. Options for such recipients include kidney paired donation (KPD) or desensitization methodology to reduce blood antibody response.
Objective: The objective of this study is to report on the first North America experience in ABOi living donor kidney transplantation using Glycosorb ABO immunoadsorption columns.