Attenuating Vibrio harveyi Virulence Through Quorum Sensing Interference Using Piperine: An In Vitro and In Silico Approach.

Aquaculture diseases caused by pathogens such as Vibrio spp., amplified by the emergence of antibiotic resistance, threaten the aquaculture industry. Due to its critical role in regulating the expression of genes related to antibiotic resistance and virulence, quorum sensing (QS) was proved to be an ideal target in disease control.

Extract from the fermented soybean product Natto inhibits Vibrio biofilm formation and reduces shrimp mortality from Vibrio harveyi infection.

Many bacteria, including Vibrio pathogens of shrimp, need to colonize and/or form biofilms in hosts or the environment to cause disease. Thus, one possible control strategy for shrimp Vibriosis is biofilm inhibition. With this objective, an extract from the Japanese fermented soybean product, Natto was tested with the luminescent shrimp pathogen Vibrio harveyi (VH) for its ability to inhibit or degrade biofilm and to interfere with cell growth in broth.