Antimalarial and antimicrobial substances from the endophytic fungus BCC71876.

Three previously undescribed compounds including 2',3'-dihydroxy-4,5',4″-trimethoxy--terphenyl (), 5-methoxyhydroperoxyco-chliodinol (), and 5-(3',3'-dimethylallyl)indole-3-oxoacetic acid (), along with fifteen known compounds ( - and ), were isolated from the endophytic fungus, BCC71876. The chemical structures were determined by NMR spectral information as well as the comparison with those closely related compounds reported in the literature. The compounds isolated were evaluated for biological properties including antimalarial, anti-TB, anti-plant pathogenic fungal, antibacterial, and cytotoxicity.

Description of Streptomyces siderophoricus sp. nov., a promising nocardamine-producing species isolated from the rhizosphere soil of Mangifera indica.

An actinomycete, designated strain CH9-7, was isolated from the rhizosphere soil of Mangifera indica. The morphological and chemotaxonomic properties, such as the production of spiral spore chains and the presence of LL-diaminopimelic acid in the peptidoglycan, showed that it belongs to the genus Streptomyces. Based on the 16S rRNA gene analysis, it was confirmed that strain CH9-7 was a member of the genus Streptomyces and revealed 99.

Pradimicin U, a promising antimicrobial agent isolated from a newly found Nonomuraea composti sp. nov.

Pradimicin U is a new dihydrobenzo[a]naphthacenequinone compound found to be active on a screen designed to investigate compounds with antimicrobial activity, produced by the actinomycete designated strain FMUSA5-5. The strain was isolated from a bio-fertilizer of Musa spp. collected from Suphanburi province, Thailand.

Antimicrobial properties of unusual eremophilanes from the endophytic Diaporthe sp. BCC69512.

Six undescribed infrequent eremophilane derivatives including diaportheremopholins A - F and its previously undescribed side chain (E)-2-methyloct-2-enoic acid, together with three known compounds (testacein, xestodecalactones B and C), were isolated from the endophytic fungus Diaporthe sp. BCC69512. The chemical structures were determined based on NMR spectroscopic information in conjunction with the evidence from NOESY spectrum, Mosher's application, and chemical reactions for corroborating the absolute configurations.

Actinomycetospora termitidis sp. nov., an insect-derived actinomycete isolated from termite (Odontotermes formosanus).

Strain Odt1-22, an insect-derived actinomycete was isolated from a termite (Odontotermes formosanus) that was collected from Chanthaburi province, Thailand. Strain Odt1-22 was aerobic, Gram-stain-positive, and produced bud-like spore chain on the substrate hypha. According to chemotaxonomic analysis, strain Odt1-22 contained meso-diaminopimelic acid in peptidoglycan and the whole-cell hydrolysates contained arabinose, galactose, glucose, and ribose.

Frenolicins H and I from the caterpillar-associated sp. TBRC17107.

Two undescribed frenolicins H and I ( and ) along with six previously described frenolicin analogues [frenolicins A (), B (), UCF76-B (), E - G ( - )] and two anthraquinones [3,8-dihydroxy-1-propylanthraquinone-2-carboxylic acid () and 3,8-dihydroxy-1-propylanthraquinone ()] were isolated from a longkong bark eating caterpillar-derived sp. TBRC17107. The chemical structures were determined by NMR spectroscopic information and HRESIMS data.

sp. nov., a Novel Actinobacterium Isolated from Peat Swamp Forest Soil That Produces Ansamycin Derivatives and Nocardamines.

Actinomycetes, especially the genus , are one of the most promising sources of bioactive natural products. In this study, a novel strain, RCU-064, was isolated from a soil sample collected from a peat swamp forest in Thailand. Strain RCU-064 showed the highest 16S rRNA gene sequence similarity (99.

sp. nov., an endophytic actinobacterium isolated from the root tissue of .

An endophytic actinobacterium, designated strain PLAI 1-29, was isolated from the root tissue of collected from Pathum Thani province, Thailand. Strain PLAI 1-29 was characterized using a polyphasic taxonomic approach. It typically exhibited morphological and chemotaxonomic properties of the genus .

Streptomyces telluris sp. nov., a promising terrestrial actinobacterium with antioxidative potentials.

An actinomycete strain, AA8, which produced a long straight chain of spores (verticillati type), was isolated from the rhizosphere soil of Mangifera indica in Bangkok, Thailand. A polyphasic taxonomic study was carried out to establish the taxonomic position of the strain. Strain AA8 formed a tight taxonomic position in the 16S rRNA gene tree with Streptomyces roseifaciens MBT76.

sp. nov., an actinobacterium isolated from hot spring soil.

An actinobacterium strain, PPF5-17, was isolated from hot spring soil collected from Chiang Rai province, Thailand. The strain exhibited morphological and chemotaxonomic properties similar to those of members of the genus . Colonies of PPF5-17 were strong pinkish red and turned black after sporulation in ISP 2 agar medium.

New insights into the neuroprotective and beta-secretase1 inhibitor profiles of tirandamycin B isolated from a newly found Streptomyces composti sp. nov.

Tirandamycin (TAM B) is a tetramic acid antibiotic discovered to be active on a screen designed to find compounds with neuroprotective activity. The producing strain, SBST2-5, is an actinobacterium that was isolated from wastewater treatment bio-sludge compost collected from Suphanburi province, Thailand. Taxonomic characterization based on a polyphasic approach indicates that strain SBST2-5 is a member of the genus Streptomyces and shows low average nucleotide identity (ANI) (81.

sp. nov., a novel marine actinobacterium isolated from seawater in the upper gulf of Thailand.

An actinobacterium strain, SW21, was isolated from seawater collected in the upper Gulf of Thailand. Cells were Gram-stain-positive, aerobic and rod-shaped. Growth was observed from 15 to 37 °C and at pH 6-8.

Micromonospora thermarum sp. nov., an actinobacterium isolated from hot spring soil.

An actinomycete, designated strain HSS6-12, was isolated from hot spring sediment collected from Ranong province, Thailand. The strain showed taxonomic characteristics consistent with those of members of the genus Micromonospora. HSS6-12 produced a single spore directly on the substrate mycelium, and no aerial mycelium was detected.

sp. nov., an actinobacterium isolated from peat swamp forest soil.

An actinobacterium strain PLK6-54 was isolated from Lankwai peat swamp forest soil collected from Yala province, Thailand. Strain PLK6-54 exhibited morphological and chemotaxonomic properties described for the genus . It formed a spiral spore chain directly on aerial mycelium.

Cellular responses to 8-methyl nonanoic acid, a degradation by-product of dihydrocapsaicin, in 3T3-L1 adipocytes.

Background: Capsaicinoids, such as dihydrocapsaicin (DHC), exert the health-promoting effects of chili peppers on energy metabolism. The metabolic responses to capsaicinoids are primarily mediated through transient receptor potential cation channel subfamily V member 1 (TRPV1). However, the varying contributions of their metabolites to beneficial health outcomes remain unclear.

Antimalarial and antimicrobial substances isolated from the endophytic actinomycete, Streptomyces aculeolatus MS1-6.

Seven undescribed compounds, including four naphthoquinone terpenoids (aculeolatins A - D), one rare 2-nitropyrrole terpenoid (nitropyrrolin F), and two hydroxamate siderophores (aculeolamides A and B) and one further undescribed compound (2,5,7-trihydroxy-3,6-dimethylnaphthalene-1,4-dione), together with eleven known compounds (arromycin, phenaziterpene A, nitropyrrolin A, heronapyrroles A and B, salaceyin A, 5,7-dihydroxy-2-isopropylchromone, 1-hydroxyphenazine, 1-methoxyphenazine, 1-acetyl-β-carboline, and N-(2-phenylethyl) acetamide), were isolated from the cultures of the endophytic Streptomyces aculeolatus MS1-6. The structures of the isolated compounds were determined using NMR spectroscopy and corroborated using chemical modification. These compounds exhibited a broad spectrum of biological activities, including antimalarial (IC 6.

sp. nov., an actinomycete isolated from compost of (Lam.).

A member of the genus , designated RCPT1-4, was isolated from compost of (Lam.), collected from an agricultural area in Rayong province, Thailand. The spore morphology and the presence of ll-diaminopimelic acid in the peptidoglycan indicate that RCPT1-4 shows the typical properties of members of the genus .

sp. nov., an endophytic actinomycete isolated from the root of .

An endophytic -like micro-organism, designated strain PRB2-1 was isolated from root tissue of (Linden and André) G.S. Bunting.

Potential antibiotic production of sp. nov., isolated from the root of .

Endophytic actinobacterial strain 3R004 was isolated from a root of collected in Thailand. In this report, the taxonomic position of this strain is described using a polyphasic approach. Based on the morphological characteristics and chemical composition of its cells, strain 3R004 was identified as a member of the genus .

Streptomyces endocoffeicus sp. nov., an endophytic actinomycete isolated from Coffea arabica (L.).

An aerobic, non-motile, Gram-stain positive actinomycete, designated strain CA3R110, was isolated from the surface-sterilised root of Coffea arabica L. collected from Lampang Province, Thailand. 16S rRNA gene sequence analysis indicated that strain CA3R110 was a member of the genus Streptomyces and showed the closest similarities to Streptomyces buecherae AC541 (99.

sp. nov., an actinomycete isolated from soil.

An actinobacterium, strain CH5-8, which formed spiral chains of spore arising from the aerial mycelium, was isolated from rhizosphere soil of spp The organism exhibited vivid greenish yellow substrate mycelium and easily produced the medium grey aerial spore mass on ISP2 medium. The typical chemotaxonomic properties of members of the genus were observed for strain CH5-8, e.g.

sp. nov., an endophytic actinomycete isolated from the root of (L.).

An endophytic actinobacterium, designated strain CA1R205, was isolated from the surface-sterilized root of L. collected from Ratchaburi province, Thailand. The taxonomic position of this strain was evaluated using a polyphasic approach.

Bioactive Dimeric Tetrahydroxanthones with 2,2'- and 4,4'-Axial Linkages from the Entomopathogenic Fungus .

Thirteen tetrahydroxanthone dimers, -ascherxanthone A (), ascherxanthones C-G (-), and confluxanthones A-G (-), were isolated from the entomopathogenic fungus BCC53152. The chemical structures were determined based on analysis of NMR spectroscopic and mass spectrometric data. The absolute configurations of compounds and were confirmed by single-crystal X-ray diffraction experiments, while the configurations of other compounds were assigned based upon evidence from NOESY and NOEDIFF experiments, modified Mosher's method, and ECD spectroscopic data together with biogenetic considerations.

Abyssomicin derivatives from the rhizosphere soil actinomycete Microbispora rhizosphaerae sp. nov. TBRC6028.

Three undescribed abyssomicin derivatives, including microbimisin, abyssomicins Z1, and Z2, were isolated from the soil actinomycete Microbispora rhizosphaerae sp. nov. TBRC6028.