Publications by authors named "Patsy Polston"

Low racial/ethnic diversity among public health academics undermines our research, teaching, and practice. One important step for addressing this problem is to increase the diversity of applicant pools for open faculty positions. In this commentary, we share our experience conducting a tenure-track faculty search at a large public university.

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Racism is a public health problem. Systems, structures, policies, and practices perpetuate a culture built on racism. Institutional reform is needed to promote antiracism.

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To assess circulation of the Sabin 2 poliovirus vaccine strain in Madagascar after its withdrawal from the oral polio vaccine in April 2016, a reinforced poliovirus surveillance was implemented in three regions of Madagascar from January 2016 to December 2017. Environmental samples and stool specimens from healthy children were screened using the Global Polio Laboratory Network algorithm to detect the presence of polioviruses. Detected polioviruses were molecularly typed and their genomes fully sequenced.

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Article Synopsis
  • A new treatment strategy called consecutive alternating administration (CAA) was developed for enterovirus infections using a combination of antiviral drugs, showing no drug resistance and increased effectiveness in a mouse model infected with coxsackievirus B1 (CVB1).
  • Researchers analyzed brain samples from mice treated with CAA and monotherapies for viral RNA mutations using next-generation sequencing, revealing specific genetic changes associated with drug effects.
  • The findings suggest that the CAA method leads to distinct mutations in the viral genome, which may contribute to the treatment's high efficacy and prevention of drug resistance.
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Article Synopsis
  • Human enteroviruses are diverse, with over 100 serotypes across four species, causing various illnesses, making their detection and classification crucial for research and understanding viral evolution.
  • A new rapid and sensitive method was developed to detect and classify all human enteroviruses from mixed samples, using specially designed primers to target key viral genome regions.
  • This method successfully sequenced the full genomes of most enteroviruses tested, allowing for differentiation of various types in both mixed and pure samples.
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Enteroviruses are among the most common viruses infecting humans and can cause diverse clinical syndromes ranging from minor febrile illness to severe and potentially fatal diseases. Enterovirus species C (EV-C) consists of more than 20 types, among which the three serotypes of polioviruses, the etiological agents of poliomyelitis, are included. Biodiversity and evolution of EV-C genomes are shaped by frequent recombination events.

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Human enteric adenoviruses (HAdVs) are commonly detected in waters contaminated with human fecal material and persistent in the environment. Detecting infectious enteric HAdVs is limited by the difficulty of growing them in cell cultures. Recently, an improved cell line (293 CMV) has been described, which enhanced the propagation of enteric HAdVs (Kim et al.

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A protocol for the rapid detection and semi-quantification of human enteric adenovirus based on the quantification of viral mRNA during cell culture infectivity assay was developed. Infectivity assays for adenovirus incorporated cell culture and reverse transcription real-time PCR, where viral mRNA detection was used to monitor the progress of adenovirus infection (CC/mRNA qPCR). The cell line used was G293.

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