Publications by authors named "Patrycja Maciak"
The nervous system's regenerative potential has sparked interest in exploring novel approaches to generate Schwann cell-like cells (SC-LCs) from chicken blastoderm (B)-derived embryonic stem cells (B-ESCs). This study investigates the hypothesis that specific growth factors, when used during ex-ovo culture, can induce the differentiation of chicken B-ESCs into cells resembling Schwann cells (SCs). Blastodermal cells (BCs) were isolated from in vivo-fertilized eggs at stage X followed by 14-d proliferative culture (PRC) of B-ESCs and subsequent 14-d glial/neurolemmogenic differentiation culture (DFC).
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- Boldenone (Bdn) and nandrolone (Ndn) are anabolic steroids that may pose a risk of cancer transformation in pig ovarian stem cells and can activate the NF-κB pathway.
- The study aimed to determine if Bdn and Ndn activate the NF-κB pathway through the membrane androgen receptor ZIP-9 by analyzing gene expression and protein localization associated with this pathway.
- Findings indicated an increase in certain phosphorylated proteins confirming NF-κB activation, but also suggested that ZIP-9 may not play a significant role in regulating this pathway due to reduced expression levels.
Long non-coding RNAs (lncRNAs) constitute the largest and most diverse class of non-coding RNAs. They localize to the nucleus, cytoplasm, or both compartments, and regulate gene expression through various mechanisms at multiple levels. LncRNAs tend to evolve faster and present higher tissue- and developmental stage-specific expression than protein-coding genes.
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