Association between local atherosclerosis and renal cell carcinomas.

Objective: Atherosclerosis induce changes in reactive oxygen species and oxidative stress by hypoxia leading to oxidative DNA damage and therefore it could be expected that the cancer risk in patients with atherosclerotic diseases is increased.

Materials And Methods: The present study therefore aimed to morphometrically compare atherosclerotic changes (e.g.

Tissue microarrays from renal cell tumors: exclusion criteria and rate of exclusion.

Objectives: Exclusion of tissue microarray (TMA) cores can cause the total loss of a tumor case, and this can have a potentially negative effect on the results of TMA-based studies. The main aim of this study was to evaluate the loss of informative cores having cut a given number of slices from a TMA block. A further objective was to investigate the effect in various subtypes of renal cell tumors and the detailed reasons for the loss of informative cores.

Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1beta-treated human peritoneal mesothelial cells.

The peritoneal mesothelium acts as a regulator of serosal responses to injury, infection, and neoplastic diseases. After inflammation of the serosal surfaces, proinflammatory cytokines induce an "activated" mesothelial cell phenotype, the mitochondrial aspect of which has not previously been studied. After incubation of cultured human peritoneal mesothelial cells with interleukin (IL)-1beta for 48 h, respiratory activity of suspended cells was analyzed by high-resolution respirometry.

Perforated Meckel's diverticulum presenting as a gastrointestinal stromal tumor: a case report.

Tumors and perforation of Meckel's diverticulum are rare manifestations. A gastrointestinal stromal tumor in a Meckel's diverticulum causing perforation and subsequent peritonitis in a 75-year-old man is presented. The literature on tumors in Meckel's diverticulum is extensively reviewed and discussed.

Disruption of the integrity of human peritoneal mesothelium by interleukin-1beta and tumor necrosis factor-alpha.

Inflammatory and neoplastic disease processes of the abdominal cavity are frequently associated with disruption of the integrity of the peritoneal mesothelium. In the present study, we analyzed the effects of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) on the morphology and expression of adhesion molecules of human peritoneal mesothelial cells (HPMC). Treatment of HPMC with IL-1beta and TNF-alpha resulted in a time- and dose-dependent alteration of the normal cobblestone morphology of the mesothelium with loss of polarization, cellular retraction and exposure of the submesothelial matrix.