Publications by authors named "Patrizia Ceccarelli"
Feasibility and Safety of Bridging Antiplatelet Therapy with Cangrelor in Neuro-Oncology: A Preliminary Experience.
J Neurol Surg A Cent Eur Neurosurg
January 2025
Article Synopsis
- Antiplatelet therapy is crucial for preventing blood clots in patients with recent heart issues, but urgent surgeries pose challenges in balancing bleeding and clotting risks.
- Current literature lacks a consensus on the best approach to manage antiplatelet therapy during surgery, particularly for neurosurgical cases, although some guidelines exist for other types.
- In a reported case, a patient undergoing brain tumor surgery safely used an intravenous P2Y inhibitor (cangrelor) as a bridging therapy, showing no bleeding or heart-related problems during and after the procedure.
Background: Intravenous thrombolysis and endovascular reperfusion represent nowadays the standard treatment for acute ischemic stroke. However, ineffective reperfusion may occur, representing a major negative prognostic factor on clinical outcome. Extracranial-intracranial (EC-IC) bypass revascularization procedure in an acute setting appears as a promising tool to increase reperfusion rates and improve clinical outcome in a highly selected population refractory or ineligible for standard reperfusion therapies.
View Article and Find Full Text PDFPurpose: This study aimed at investigating the mechanisms underlying the oxygenation response to proning and recruitment maneuvers in coronavirus disease 2019 (COVID-19) pneumonia.
Methods: Twenty-five patients with COVID-19 pneumonia, at variable times since admission (from 1 to 3 weeks), underwent computed tomography (CT) lung scans, gas-exchange and lung-mechanics measurement in supine and prone positions at 5 cmHO and during recruiting maneuver (supine, 35 cmHO). Within the non-aerated tissue, we differentiated the atelectatic and consolidated tissue (recruitable and non-recruitable at 35 cmHO of airway pressure).
Background: The present study was performed to evaluate intracranial pressure (ICP) variations after antipyretic therapy and their relationship to ICP at baseline (ICPbas) in acute brain injury (ABI) patients.
Methods: We completed a retrospective analysis on data derived from 2 previously published prospective observational studies. The first study involved 32 ABI patients and was performed to elucidate the cerebral and hemodynamic effects of intravenous (IV) paracetamol.