Type 1 diabetes (T1DM) in children and adolescents of immigrated families in Emilia-Romagna (Italy).

Background And Aim Of The Work: The etiology and natural history of T1DM are still unknown but certainly both genetics and environmental factors contribute to the development of the disease. Migration studies are an important tool to better understand the role of the environment. The aim of this study was to investigate some variables in diabetic children of immigrant families living in Emilia-Romagna compared with Italian diabetic children living in the same region.

Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.

Glucokinase is essential for glucose-stimulated insulin release from the pancreatic beta-cell, serving as glucose sensor in humans. Inactivating or activating mutations of glucokinase lead to different forms of glucokinase disease, i.e.

The continuous glucose monitoring system (CGMS) in patients with beta-thalassemia major and impaired glucose homeostasis: preliminary results.

Impaired glucose tolerance (IGT) and diabetes mellitus (DM) are well known complications in ?-thalassemia major (TM). In recent years new technologies have become available for the management of these conditions, including the continuous glucose monitoring system (CGMS). We implanted CGMS in six TM patients with abnormal glucose homeostasis after an oral glucose tolerance test (OGTT).