Advanced Analysis of OCT/OCTA Images for Accurately Differentiating Between Glaucoma and Healthy Eyes Using Deep Learning Techniques.

Purpose: To evaluate the discriminative power of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images, identifying the best image combination for differentiating glaucoma from healthy eyes using deep learning (DL) with a convolutional neural network (CNN).

Methods: This cross-sectional study included 157 subjects contributing 1,106 eye scans. We used en-face images of the superficial and choroid layers for OCTA-based vessel density and OCT-based structural thickness of the macula (M) and optic disc (D).

Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries.

Background: The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe.

Methods: A cross-sectional analysis including 518 treatment-naïve patients with retinoblastoma residing in 40 European countries and 1024 treatment-naïve patients with retinoblastoma residing in 43 African countries.

Global Retinoblastoma Presentation and Analysis by National Income Level.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale.

DNA alteration-based classification of uveal melanoma gives better prognostic stratification than immune infiltration, which has a neutral effect in high-risk group.

Background: In uveal melanomas, immune infiltration is a marker of poor prognosis. This work intended to decipher the biological characteristics of intra-tumor immune population, compare it to other established biomarkers and to patients' outcome.

Methods: Primary, untreated, and mainly large uveal melanomas with retinal detachment were analyzed using: transcriptomic profiling (n = 15), RT-qPCR (n = 36), immunohistochemistry (n = 89), Multiplex Ligation-dependent Probe Amplification (MLPA) for copy number alterations (CNA) analysis (n = 89), array-CGH (n = 17), and survival statistics (n = 86).

Visual acuity and factors influencing automobile driving status in 1,000 patients age 60 and older.

Background: The objective of this prospective observational study was to evaluate the number of people driving in accordance with common legal standards, measured through far binocular visual acuity, and to identify variables associated with driving habits outside of legal standards.

Methods: Subjects aged 60 years and older were recruited at a tertiary referral center (University Hospital of Mont-Godinne, Yvoir, Belgium). Ophthalmological examination was conducted in all subjects by an ophthalmologist.

Allergic contact dermatitis following ocular use of corticosteroids.

Aim: To study the clinical features and to identify the molecules responsible for contact-allergic reactions following ocular use of corticosteroid (CS) preparations.

Design: Observational case series.

Methods: We reviewed the clinical data, the patch test results, and sensitization sources in patients with a CS contact allergy, who have been patch tested in the K.

Cytomegalovirus retinitis after low-dose intravitreous triamcinolone acetonide in an immunocompetent patient: a warning for the widespread use of intravitreous corticosteroids.

We report the case of an immunocompetent 78-year-old woman who developed cytomegalovirus (CMV) retinitis after a single intravitreous injection of triamcinolone acetonide (IVTA). Review of medical records. The patient with macular edema secondary to branch retinal vein occlusion developed peripheral retinitis with hemorrhagic and inflammatory vascular sheathing 3 months after IVTA.

Conjunctival nevi clinical features and therapeutic outcomes.

Objective: To determine the epidemiology and the clinical and therapeutic outcomes of conjunctival nevi and to identify the clinical variables statistically associated with operative excision.

Design: Prospective, observational, noncomparative case series.

Participants: Two hundred fifty-five patients with the clinical diagnosis of conjunctival nevus.

Physiological diurnal variability and characteristics of the ocular pulse amplitude (OPA) with the dynamic contour tonometer (DCT-Pascal).

Purpose: The Pascal dynamic contour tonometer (DCT) allows measurement of intraocular pressure (IOP) independently of corneal properties. It records, simultaneously, haemodynamic IOP fluctuations and the difference between the systolic and the diastolic IOP corresponding to the ocular pulse amplitude (OPA). The OPA indirectly reflects choroidal perfusion and could be considered as an independent risk factor in glaucoma.

Choroidal metastasis from carcinoma of the bladder.

Purpose: To report choroidal metastasis from the newly described nested variant of urothelial carcinoma of the bladder as the initial presentation of metastatic disease.

Methods: A 58-year-old man with a history of urothelial bladder carcinoma developed progressive decreased visual acuity in the right eye. Fundus examination showed an amelanotic choroidal tumor simulating a choroidal melanoma.

Susac syndrome in four male patients.

Purpose: To report the clinical and imaging features in four male patients presenting with Susac syndrome, a microangiopathy affecting the brain, the retina, and the cochlea.

Methods: Retrospective review of clinical data, fluorescein angiograms, and magnetic resonance imaging findings in these four cases.

Results: All four patients were young men (range, 20-35 years).

Anterior segment imaging using optical coherence tomography and ultrasound biomicroscopy in secondary pigmentary glaucoma associated with in-the-bag intraocular lens.

A 43-year-old man with high myopia developed unilateral pigmentary glaucoma with recurrent episodes of painless blurred vision in the left eye following uneventful phacoemulsification. Bilateral cataract surgery was performed with capsular bag implantation of a +4.00 diopter AcrySof MA60 intraocular lens (IOL) (Alcon Laboratories) followed by a neodymium:YAG laser capsulotomy.

Primary orbital melanoma treated with iodine-125 plaque radiotherapy.

Purpose: To report a case of primary orbital melanoma successfully managed by custom-designed iodine-125 plaque.

Design: Case report.

Methods: A 59-year-old man with no systemic or secondary melanocytic tumor was diagnosed with primary orbital melanoma after transconjunctival incisional biopsy.

Retinoblastoma and deletion of the long arm of chromosome 13: an underestimated diagnosis?

We report an infant with normal neurological development and phenotype who developed bilateral retinoblastoma (RB). This patient, despite lack of dysmorphic features, demonstrated constitutional abnormality of the long arm of chromosome 13 on standard karyotype. We recommend systematic cytogenetic examinations complemented by fluorescent in situ hybridization as second-line screening in all patients suspected for hereditary RB despite negative RB1 molecular screening and normal phenotype.

Intraorbital implantation of a stimulating electrode for an optic nerve visual prosthesis. Case report.

Research into visual prosthetics is expected to revolutionize the treatment of blind patients with incurable outer retinal degenerative disease. Substantial evidence shows that useful visual sensations can be produced by controlled electrical stimulation of the optic nerve. To make the optic nerve visual prosthesis more acceptable, implantation techniques safer and less invasive than those previously used have been developed.

Atypical spherical deposition on vitreoretinal interface associated with toxoplasmic chorioretinitis.

Purpose: To report the clinical and optical coherence tomography features of spherical deposits associated with recurrent toxoplasmic chorioretinitis.

Methods: Case report.

Results: Atypical, 100 microm to 150 microm, greyish deposits appeared along retinal arteries and veins as well as on the vitreoretinal interface in the macula of a 44-year-old Caucasian woman while she was being treated for recurrent toxoplasmic chorioretinitis with antiparasitic drugs and subconjunctival injection of betamethasone.

Unilateral retinoblastoma, lack of familial history and older age does not exclude germline RB1 gene mutation.

Conclusive identification of RB1 mutations in retinoblastoma is predicted to improve the clinical management of affected children and relatives. However, despite clear clinical benefits, RB1 screening remains difficult, most of the alterations being unique and randomly distributed throughout the entire coding sequence. In this report, we present the results of a constitutional RB1 analysis undertaken in our institution over the last four years.

Porous polyethylene orbital implant in the pediatric population.

Purpose: To determine the incidence of complications of primary insertion of porous polyethylene orbital implant in the pediatric population.

Design: Interventional case series.

Methods: Prospective nonrandomized case series of 36 eyes of 36 patients under age 15 years who underwent primary placement of an anteriorly wrapped spherical porous polyethylene orbital implant from March 1998 to August 2002, with at least 17 months of follow-up.

Embryonal rhabdomyosarcoma presenting as conjunctival tumor.

The authors report the case of a 10-year-old girl who presented with a focal conjunctival lesion of the right eye. Conjunctival biopsy was performed and revealed an embryonal rhabdomyosarcoma. She received chemotherapy alone according to the Malignant Mesenchymal Tumor 95 Study (stage II nonalveolar orbital tumors) and is still in complete remission 6 months after the completion of treatment.

Adjuvant indocyanine green in transpupillary thermotherapy for choroidal melanoma.

Objective: To determine the effect of indocyanine green (ICG) injection on the regression pattern of choroidal melanomas treated with transpupillary thermotherapy (TTT).

Design: Prospective, randomized, controlled study.

Participants: Of the 60 patients with posterior pole choroidal melanoma, 30 were managed with TTT alone (control group), and 30 received adjuvant ICG before TTT.