Publications by authors named "Patrick Yizhi Cai"
Article Synopsis
- Branched DNA molecules play a critical role in DNA processes like replication and repair, making their structural understanding essential for grasping these biological mechanisms.
- While gel electrophoresis offers a bulk analysis of DNA, direct visualization at the single-molecule level is necessary but requires pure samples free from unwanted DNA interference.
- The study focuses on overcoming challenges in isolating large, branched DNA structures, specifically in E. coli, by utilizing techniques like β-agarase digestion and multiple rounds of gel electrophoresis for enhanced sample purity.
