Publications by authors named "Patrick Xu"
The multi-sectoral metabolisms of substance and energy in rural areas are complex, whose optimization is the key to realize resource recycling and energy cascade utilization. Through Substance Flow Analysis (SFA), we establish a Multi-sectoral Metabolism Analysis Model specific to rural areas (MMAM-rural), and investigated the multi-sectoral metabolisms of Liujiadian Town in Beijing city. We simulate the water, energy and nutrients (carbon, nitrogen and phosphorus) metabolisms of a total of five sectors (water, waste management, livestock husbandry, forestry, and residential sectors), and identify the key metabolic flows significant for improving regional metabolism performance of Liujiadian Town.
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- Ligand binding causes the epidermal growth factor receptor (EGFR) to undergo changes that activate its signaling pathways, but how unstimulated EGFR molecules interact on the cell surface is not well understood.
- A new method called selective crosslinking (S-CROSS) was used to study homodimer formation of EGFR in living cells, revealing that unstimulated EGFR forms homodimers and has similar interaction efficiencies as when stimulated by the ligand EGF.
- The study found that EGFR homodimers have increased kinase activation when stimulated and that examination of spontaneous phosphorylation levels correlates with the presence of these dimer species, offering a new approach to understand receptor interactions and the impact of potential cancer drug targets.