Publications by authors named "Patrick Tusiime"

Environmental education research methods often focus on measuring changes in people's attitudes toward conservation. While attitudes are an important indicator of change, it is critical to target incentivised behaviour because conservation efforts often involve behavioural changes that are costly to one's self (e.g.

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Introduction: Respiratory illness is the most common childhood disease globally, especially in developing countries. Previous studies have detected viruses in approximately 70-80% of respiratory illnesses.

Methods: In a prospective cohort study of 234 young children (ages 3-11 years) and 30 adults (ages 22-51 years) in rural Western Uganda sampled monthly from May 2019 to August 2021, only 24.

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Reverse zoonotic respiratory diseases threaten great apes across Sub-Saharan Africa. Studies of wild chimpanzees have identified the causative agents of most respiratory disease outbreaks as "common cold" paediatric human pathogens, but reverse zoonotic transmission pathways have remained unclear. Between May 2019 and August 2021, we conducted a prospective cohort study of 234 children aged 3-11 years in communities bordering Kibale National Park, Uganda, and 30 adults who were forest workers and regularly entered the park.

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Introduction: Respiratory disease is a major cause of morbidity and mortality in the developing world, but prospective studies of temporal patterns and risk factors are rare.

Methods: We studied people in rural Western Uganda, where respiratory disease is pervasive. We followed 30 adults (ages 22-51 years; 534 observations) and 234 children (ages 3-11 years; 1,513 observations) between May 2019 and July 2022 and collected monthly data on their respiratory symptoms, for a total of 2,047 case records.

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On April 20, 2018, the Kween District Health Office in Kween District, Uganda reported 7 suspected cases of human anthrax. A team from the Uganda Ministry of Health and partners investigated and identified 49 cases, 3 confirmed and 46 suspected; no deaths were reported. Multiple exposures from handling the carcass of a cow that had died suddenly were significantly associated with cutaneous anthrax, whereas eating meat from that cow was associated with gastrointestinal anthrax.

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  • - The Uganda Ministry of Health announced a cholera outbreak in the Kyangwali Refugee Settlement on February 23, 2018, with over 60 individuals affected, leading to an investigative study to assess the outbreak's extent and transmission methods.
  • - Investigators defined cholera cases based on symptoms and conducted a case-control study, finding a case-fatality rate of 2.1% with the highest impact on individuals from the Democratic Republic of Congo.
  • - The outbreak lasted four months and was linked to contaminated stream water resulting from open defecation, with an overall attack rate of 3.2 per 1000 people in Hoima District.
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  • * The country conducted a thorough assessment using WHO and CDC tools, mapping 40 crossing points and over 500 locations in 12 high-risk districts with fewer than 50% preparedness scores.
  • * A national EVD preparedness plan was developed, focusing on improving surveillance, laboratory capacity, healthcare resources, and risk communication to combat potential EVD importation and spread.
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Background: Since the declaration of the 10th Ebola Virus Disease (EVD) outbreak in DRC on 1st Aug 2018, several neighboring countries have been developing and implementing preparedness efforts to prevent EVD cross-border transmission to enable timely detection, investigation, and response in the event of a confirmed EVD outbreak in the country. We describe Uganda's experience in EVD preparedness.

Results: On 4 August 2018, the Uganda Ministry of Health (MoH) activated the Public Health Emergency Operations Centre (PHEOC) and the National Task Force (NTF) for public health emergencies to plan, guide, and coordinate EVD preparedness in the country.

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Uganda is currently implementing the Global Health Security Agenda (GHSA), aiming at accelerating compliance to the International Health Regulations (IHR) (2005). To assess progress toward compliance, a Joint External Evaluation (JEE) was conducted by the World Health Organization (WHO). Based on this evaluation, we present the process and lessons learned.

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: Low-income countries with relatively weak-health systems are highly vulnerable to public health threats. Effective public health system with a workforce to investigate outbreaks can reduce disease impact on livelihoods and economic development. Building effective public health partnerships is critical for sustainability of such a system.

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  • In October 2017, the first positive case of the Marburg virus in Kween District, Uganda led to an immediate outbreak response, involving specialized teams for case management and community engagement.
  • Epidemiological investigations identified a total of 70 individuals, with four confirmed cases of Marburg virus disease (MVD), resulting in a high case fatality rate of 75% within a single family.
  • Rapid detection and effective containment measures, including timely laboratory testing and trained response teams, successfully controlled the outbreak within a month, preventing further spread.
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  • The Integrated Disease Surveillance and Response (IDSR) strategy was implemented in Uganda to enhance the management of infectious diseases, but challenges remain despite improvements in reporting and response following training in 2015-2016.
  • Health workers reported positive outcomes such as better case detection and data analysis but identified obstacles like insufficient trained staff, funding issues, and high turnover rates.
  • Recommendations to enhance IDSR effectiveness include incorporating training in pre-service education, establishing mentorship programs, and securing more funding for district-level support.
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  • * Four cases of human RVF were identified, three confirmed by a specific viral test and one by serological methods, while a small number of livestock also tested positive for the virus.
  • * Genetic analysis showed that this RVF strain was linked to a previous outbreak in Kenya, marking Uganda's first RVF identification in nearly five decades and its tenth viral hemorrhagic fever outbreak since 2010.
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Background: Uganda is a low income country that continues to experience disease outbreaks caused by emerging and re-emerging diseases such as cholera, meningococcal meningitis, typhoid and viral haemorrhagic fevers. The Integrated Disease Surveillance and Response (IDSR) strategy was adopted by WHO-AFRO in 1998 as a comprehensive strategy to improve disease surveillance and response in WHO Member States in Africa and was adopted in Uganda in 2000. To address persistent inconsistencies and inadequacies in the core and support functions of IDSR, Uganda initiated an IDSR revitalisation programme in 2012.

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Uganda is prone to epidemics of deadly infectious diseases and other public health emergencies. Though significant progress has been made in response to emergencies during the past 2 decades, system weaknesses still exist, including lack of a robust workforce with competencies to identify, investigate, and control disease outbreaks at the source. These deficiencies hamper global health security broadly.

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Background: Uganda adopted and has been implementing the Integrated Disease Surveillance (IDSR) strategy since 2000. The goal was to build the country's capacity to detect, report promptly, and effectively respond to public health emergencies and priorities. The considerable investment into the program startup realised significant IDSR core performance.

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  • Rift Valley fever (RVF) is a zoonotic disease caused by the Rift Valley fever virus (RVFV), primarily affecting humans and livestock in Africa and the Middle East, with recent outbreaks in Uganda prompting a serosurvey to assess its prevalence.* -
  • In the study conducted in Kabale district, blood samples were collected from 655 humans and 1051 animals, revealing that 12% of humans and 13% of animals tested positive for RVFV, with higher risks observed among butchers and those handling raw meat.* -
  • The findings indicate that RVFV has been circulating undetected in the region despite no reported cases from 1968 to 2016, emphasizing the need for ongoing surveillance and
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  • - The study on Rift Valley Fever virus (RVF) in Kabale District, Uganda, involved a survey of 657 community members to assess their knowledge, attitudes, and practices related to RVF after two cases were diagnosed in 2016.
  • - Most participants were aware of RVF, primarily through radio, with higher perceived risks among farmers, herdsmen, and butchers compared to other occupations; however, knowledge of symptoms varied, particularly regarding animal health.
  • - Recommendations suggest that educational initiatives should focus on raising awareness and improving the use of personal protective equipment (PPE) among at-risk groups, especially among farmers, who showed lower PPE usage rates.
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On March 9, 2016, a male butcher from Kabale District, Uganda, aged 45 years, reported to the Kabale Regional Referral Hospital with fever, fatigue, and headache associated with black tarry stools and bleeding from the nose. One day later, a student aged 16 years from a different sub-county in Kabale District developed similar symptoms and was admitted to the same hospital. The student also had a history of contact with livestock.

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