Publications by authors named "Patrick Thomas Wong"
Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I.
Ziteng Wang Kylie Hoi Yan Luk Eleanor Jing Yi Cheong Sin Mun Tham Revathi Periaswami Alvin Seng Cheong Wong Patrick Thomas Wong
Drug Metab Dispos
October 2024
Article Synopsis
- This study investigates how the cancer treatment drug abiraterone affects the liver transport proteins OATP1B1 and OATP1B3, focusing on the use of coproporphyrin I (CP-I) as a biomarker to measure these effects.
- The results showed that abiraterone inhibits the uptake of CP-I through OATP1B3 but not OATP1B1, with in vitro tests revealing a moderate inhibition constant and clinical simulations indicating no significant drug interaction.
- Overall, the findings suggest that the risk of interaction between abiraterone and other drugs that rely on OATP1B transporters is low, meaning that OATP1B3 does