Long-term risk of cardiovascular disease in 5-year survivors of testicular cancer.

Purpose: To evaluate the long-term risk of cardiovascular disease (CVD) in survivors of testicular cancer (TC).

Patients And Methods: We compared CVD incidence in 2,512 5-year survivors of TC, who were treated between 1965 and 1995, with general population rates. Treatment effects on CVD risk were quantified in multivariate Cox regression analysis.

Observer variation in target volume delineation of lung cancer related to radiation oncologist-computer interaction: a 'Big Brother' evaluation.

Background And Purpose: To evaluate the process of target volume delineation in lung cancer for optimization of imaging, delineation protocol and delineation software.

Patients And Methods: Eleven radiation oncologists (observers) from five different institutions delineated the Gross Tumor Volume (GTV) including positive lymph nodes of 22 lung cancer patients (stages I-IIIB) on CT only. All radiation oncologist-computer interactions were recorded with a tool called 'Big Brother'.

Reduction of observer variation using matched CT-PET for lung cancer delineation: a three-dimensional analysis.

Purpose: Target delineation using only CT information introduces large geometric uncertainties in radiotherapy for lung cancer. Therefore, a reduction of the delineation variability is needed. The impact of including a matched CT scan with 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) and adaptation of the delineation protocol and software on target delineation in lung cancer was evaluated in an extensive multi-institutional setting and compared with the delineations using CT only.