Publications by authors named "Patrick S-Y Wong"
Most xenobiotic estrogeniety assay methods rely on direct agonist action on the estrogen receptor (ER) to approximate activation potential. Such methods do have drawbacks since some ER activating pesticides are weak or non-agonistic in ligand-binding assays. This study discusses a method that detects pesticide estrogenic actions regardless of ER ligand binding ability.
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- Cigarette smoke (CS) is known to harm respiratory tissues, but the exact interactions between CS and antioxidants like glutathione (GSH) are not fully understood.
- This study used advanced techniques to examine how CS reacts with GSH, which is important for protecting lung cells.
- The findings revealed that CS rapidly depletes GSH mostly due to reactions with specific toxic aldehydes, with implications for understanding how smoking causes respiratory damage.