Publications by authors named "Patrick S K Leung"
Article Synopsis
- CAR T cell therapy has been effective for treating blood cancers but struggles with solid tumors due to challenging tumor microenvironments.
- Research indicates that CAR T cells with a 'stem-like' phenotype and greater mitochondrial mass have better treatment outcomes.
- The study highlights that overexpressing the transcription factor FOXO1 in CAR T cells can enhance their fitness and effectiveness against solid tumors by promoting a more beneficial metabolic state.
Tumor-induced immunosuppression remains one of the major obstacles to many potentially effective cancer therapies and vaccines. Host interleukin (IL)-23 suppresses the immune response during tumor initiation, growth, and metastases, and neutralization of IL-23 causes IL-12-dependent antitumor effects. Here, we report that combining agonistic anti-CD40 monoclonal antibodies (mAb) to drive IL-12 production and anti-IL-23 mAbs to counter the tumor promoting effects of IL-23 has greater antitumor activity than either agent alone.
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