Publications by authors named "Patrick Puliti"
Article Synopsis
- Increased nucleotide biosynthesis is crucial for cancer cell growth, particularly in lymphoma, where fatty acid synthase (FASN) and lipogenesis are upregulated.
- Inhibiting FASN disrupts ribonucleotide and deoxyribonucleotide levels, halting RNA/DNA synthesis and cell cycle progression by blocking the oxidative branch of the pentose phosphate pathway (oxPPP) through the activity of phosphogluconate dehydrogenase (PGDH).
- The interaction between FASN and PGDH, influenced by NADPH levels, is key in promoting metabolic dysfunction in lymphoma, as shown by transcriptomic analyses highlighting increased expression of metabolic function genes linked to oxPPP.
