Publications by authors named "Patrick Pak-Chun Wong"
Background: Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for therapeutic development remain less understood.
Objective: We aimed to identify ICB resistance-associated druggable histone deacetylases (HDACs) and develop a readily translatable combination approach for patients with hepatocellular carcinoma (HCC).
Article Synopsis
- The study investigates how hepatocellular carcinoma (HCC) adapts to resistance against anti-PD-L1 immunotherapies, revealing the importance of tumour microenvironment remodelling.
- Researchers created resistant HCC models and used advanced techniques like single-cell RNA sequencing to explore the mechanisms of resistance, finding that certain immune cells (MDSCs) grow alongside tumours and suppress the immune response.
- The research identified a specific pathway involving PPARγ, which enhances VEGF-A production, leading to immune dysfunction and poor patient outcomes, suggesting that targeting this pathway could potentially enhance the effectiveness of immunotherapies.