Publications by authors named "Patrick O Olorunfemi"
Comparability stability studies of a live Newcastle Disease LaSota vaccine were conducted post freeze-drying and during storage at 5±2, 25±2 and 37±1 °C to demonstrate the equivalence/inequivalence of stability profiles of vaccines stabilized with peptone (reference), trehalose and starch derivatives (acetylated xerogel and carboxymethylated) from Plectranthus esculentus tubers. Variations in moisture content during storage at 5±2 °C; physical collapse/shrinkage, partial microcollapse, and hydrophilicity of lyophilisates were prominent in starch stabilized vaccines without additives. Using the mean embryo infective dose (EID) test, the derivatives and peptone stabilized vaccines had < 0.
View Article and Find Full Text PDFThe goal of this research was to assess the effects of autoclaving followed by freeze-drying on acetylated xerogel (AXS) and carboxymethylated (CMS) derivatives of Plectranthus esculentus starch as potential vaccine stabilizers. Starch extracted from tubers of P. esculentus were modified by single (carboxymethylation) and dual (acetylation followed by xerogel formation) methods.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies show a rising incidence of head and neck cancers in young people, particularly linked to high-risk human papilloma virus (hrHPV) infections, prompting this study to investigate hrHPV-related oropharyngeal carcinoma in Nigerian adults.
- The study analyzed data from 41 patients over two years, identifying a 17.1% HPV prevalence, with genotypes 16, 33, 35, and 52 being prevalent, while noting that HPV was absent in HIV-positive individuals.
- The findings highlight the association of specific hrHPV genotypes with oropharyngeal cancer in Nigeria, emphasizing the need for preventive measures, including vaccination and public awareness to combat these cancers.