Publications by authors named "Patrick Nisse"

Bed bugs are pervasive global pests that have reemerged in the last 20 years as a significant public health concern, especially in densely populated urban areas. Beyond financial losses, expenses, inconvenience, and psychological distress, bed bug infestations often necessitate chemical management, posing poisoning risks to those with an infestation. The French Poison Control Centers recorded 1056 cases of exposure to bed bug insecticide products between 1999 and 2021.

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  • The study emphasizes that while button batteries (BB) in the esophagus are recognized as emergencies, complications from BB in the intestines are not as well understood, highlighting the need for more research in this area.
  • A notable case involved a 7-month-old infant who ingested a button battery, leading to a blockage in the small intestine, which was exacerbated by his previous intestinal surgeries.
  • The literature review identified 12 severe cases of intestinal injury related to BB ingestion, suggesting that patients with a history of intestinal issues should undergo prompt endoscopic procedures to prevent serious complications like perforation or prolonged hospital stays.
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In this study, we aimed to identify the factors related to esophageal impaction following button battery (BB) ingestion in children. PilBouTox, a prospective multicentric observational cohort study, was conducted from French Poison Control Centers between June 1, 2016 and May 31, 2018. Children (0-12 years old) with BB ingestion were included.

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Introduction: In recent years, the number of patients managed by poison control centres (PCCs) has increased without a proportional increase in the number of physicians. To improve efficiency without neglecting patient follow-up, some PCCs have begun using text messages. We evaluated the difference in response rates between text messaging and traditional telephone follow-up.

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In the world, the impact of environmental conditions on the number of scorpion events was evaluated in North Africa,Middle East, and the Amazonian region but not in Europe. In mainland France, scorpion species described are Buthus occitanus (Amoreux, 1789), Belisarius xambeui (Simon, 1879) and 4 Euscorpiidae: Euscorpius concinnus (Koch, 1837), Euscorpius italicus (Herbst, 1800), Euscorpius tergestinus (Koch, 1837), and Tetratrichobothrius flavicaudis (De Geer, 1778). We aimed to describe the impact of environmental conduction on the number of scorpion events.

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Introduction: Misuse/abuse of pregabalin is increasing worldwide. French Poison Control Centers (PCCs) recently received several unusual calls regarding the recreational use of pregabalin in adolescents. This study aims to describe this new and specific population of pregabalin misusers.

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Introduction: The aim was to assess the impact of the COVID-19 pandemic on French Poison Control Centre (PCC) call characteristics.

Methods: Reported cases of xenobiotic exposures from 1 March to 30 April in 2018, 2019, and 2020 were extracted from the French National Database of Poisonings. The collected data included call, patient, and exposure characteristics for both general calls and for calls involving sentinel xenobiotic categories related to the COVID-19 pandemic.

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Background: Poisoning is one of the leading causes of admission to the emergency department and intensive care unit. A large number of epidemiological changes have occurred over the last years such as the exponential growth of new synthetic psychoactive substances. Major progress has also been made in analytical screening and assays, enabling the clinicians to rapidly obtain a definite diagnosis.

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  • The French authorities requested recommendations for screening and managing exposure to inorganic arsenic (iAs) for the population, leading to a review of existing literature on the indicators of exposure and effects in France.
  • Evaluating the toxicity of iAs involved examining studies from the past 30 years, including recent literature from 2016 to 2019.
  • The recommended biomonitoring indicator for iAs exposure is a specific urine concentration measurement, with set limits indicating overexposure; no biological indicators for early health effects exist, but skin issues like hyperpigmentation are noted as early signs of harm.
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Today, immunotherapy with Fab or F(ab') fragments is considered as a gold standard treatment for patients bitten by vipers. We compared the efficiency of two antivenoms, Viperfav and Viperatab, in mainland France in 2017-2018 with data provided by the French poison control centre (PCC). Patients with a moderate (2a and 2b) or severe (3) envenomation after a European viper bite and treated with immunotherapy were included and the markers chosen were the risk of post-antivenom treatment worsening, duration of hospital stay and persistent functional discomfort on day 15.

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  • Glyphosate-based products (GBF) are found to be more toxic than glyphosate alone, with polyethoxylated tallowamine (POEA) suspected to significantly increase this toxicity due to its irritating properties.
  • A study analyzing cases of acute poisoning reported to French Poison Control Centres from 2008 to 2014 revealed that those who ingested tallowamine-containing GBF (TA) experienced more severe symptoms compared to those who ingested non-tallowamine GBF (NTA).
  • The findings suggest that POEA is responsible for greater toxicity, causing issues such as skin irritation and severe respiratory symptoms, leading to complications like aspiration pneumonitis.
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Objectives: To describe clinical consequences of risperidone medication errors in children of less than 13 years and to estimate a clinically relevant toxic dose.

Methods: All cases of risperidone medication errors managed by French Poison Centres from 2001 to 2012 were analyzed. Inclusion criteria were a delay of at least 2 hours between ingestion and request to the FPC in asymptomatic children, an ingested dose above two-fold the maximal daily dose for children above 5 years or any symptomatic patient at the time of first contact.

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Background: Although the ingestion of button batteries is an infrequent situation, it leads to a significant risk of causing serious damage.

Objective: This study was carried out to describe all the cases of button battery ingestion recorded by the French Poison Control Centers over 16 years.

Patients And Methods: All the cases of button battery ingestion were recorded from 1 January 1999 to the end of June 2015, analysed (age, sex, number of ingested button batteries, clinical signs and treatments) and graded for severity according to the poisoning severity score.

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The ingestion of disc battery is a common problem in children and current treatment may be sometime inadequate. Ingested button batteries have the potential to cause significant morbidity and mortality. Ingestion of button batteries has been seen with increasing frequency over the last decade, particularly for children aged younger than 6 years.

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A multidisciplinary working group named "Toxicology and clinical biology" and whose members belong to the French Society of Clinical Biology (SFBC), Critical Care Medicine Society of French Language (SRLF), the French Society of Medical Emergency (SFMU), the French Society of Analytical Toxicology (SFTA), the Society of Clinical Toxicology (STC), and the National College of Biochemistry (CNBH) updated the professional practice recommendations published in 2003. These recommendations aimed the biologists who are not specialized in toxicology and more largely all the health professionals involved the management of severely poisoned patients. Among the data published in the initial edition, only the major table dealing with severe poisonings was updated, as all other supplements remained valid.

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