Publications by authors named "Patrick Mcculloch"

Article Synopsis
  • Musculoskeletal conditions affect 1.71 billion people and are complicated by diverse clinical presentations and unclear biological processes, indicating a need for targeted therapies.
  • RNA-based technologies are emerging as a promising treatment approach for joint-related issues such as osteoarthritis and rheumatoid arthritis by leveraging mRNA to enhance protein production that combats inflammation and aids tissue repair.
  • This perspective reviews recent research on mRNA therapies, highlighting encouraging preclinical and clinical findings, with the potential to transform treatment strategies for musculoskeletal disorders.
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Background: Glenohumeral instability is a common pathology, particularly in young, active patients.

Methods: A narrative review was performed to describe the history of surgical treatments for anterior shoulder instability.

Results: Open surgical techniques were first described by Bankart in 1923.

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Introduction Research is an important aspect of residency and fellowship programs across the country. Developing strategies to foster research productivity is worthwhile. An annual research project is one strategy that some programs implement.

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Article Synopsis
  • Decreased mechanical loading after orthopedic surgery can lead to muscle atrophy, prompting a review of the impact of oral protein supplementation on recovery outcomes.
  • A systematic review of 14 studies, involving 611 patients, found that protein supplementation significantly reduced muscle atrophy and enhanced functional recovery across various surgeries, including ACL reconstruction and hip surgeries.
  • The findings suggest protein supplementation is beneficial post-surgery, but further research is needed to understand long-term effects and develop targeted regimens for different patient populations.
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Osteosarcoma (OS) is the most common primary malignant bone tumor, and the current standard of care for OS includes neoadjuvant chemotherapy, followed by an R0 surgical resection of the primary tumor, and then postsurgical adjuvant chemotherapy. Bone reconstruction following OS resection is particularly challenging due to the size of the bone voids and because patients are treated with adjuvant and neoadjuvant systemic chemotherapy, which theoretically could impact bone formation. We hypothesized that an osteogenic material could be used in order to induce bone regeneration when adjuvant or neoadjuvant chemotherapy is given.

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Article Synopsis
  • Fractures are expensive to treat and can lead to serious health issues, so finding ways to identify at-risk individuals is crucial.
  • Researchers created an easy-to-use, low-cost prediction tool for assessing bone mineral density (BMD) using physical characteristics and demographic data from 492 participants.
  • The study developed a two-step model that effectively predicts total body BMD and bone mineral content (BMC), indicating potential for identifying those at risk for fractures without needing specialized equipment like DEXA.
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Purpose: To perform a systematic review to compare clinical outcomes, complications, and reoperation rates of patients undergoing the Latarjet procedure with screw vs suture-button fixation.

Methods: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to identify clinical studies directly comparing screw vs suture-button fixation for the Latarjet procedure. The search terms used were shoulder screw suture button.

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The 3 primary factors involved with preservation of the knee joint include joint alignment, meniscal status, and ligament stability (in particular that of the anterior cruciate ligament [ACL]). These factors are interdependent and result in knee joint homeostasis when all factors are stable. When a deficiency exists in one of the factors, it will affect the others.

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Osteochondral allograft transplantation is a well-described technique for the treatment of large, engaging Hill-Sachs lesions. Traditionally, osteochondral allografts are size-matched to the defect, which can be expensive and time-consuming, and the majority of described techniques require an open approach. This Technical Note describes an all-arthroscopic approach to Hill-Sachs osteochondral allograft transplantation using premade osteochondral allograft plugs, eliminating the need for size-matching and graft harvest.

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Sidelying hip abduction (SHA) is a common exercise utilized in rehabilitation to strengthen the gluteus medius (GMed). Alterations in the exercise can produce different patterns of muscular activity. No studies have examined the effect of mechanical pelvic stabilization during SHA.

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Purpose: To assess the utility of a validated wearable device (VWD) in examining preoperative and postoperative sleep patterns and how these data compare to patient-reported outcomes (PROs) after rotator cuff repair (RCR) or total shoulder arthroplasty (TSA).

Methods: Male and female adult patients undergoing either RCR or TSA were followed up from 34 days preoperatively to 6 weeks postoperatively. Sleep metrics were collected using a VWD in an unsupervised setting.

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➤ Joint alignment, meniscal status, and ligament stability are codependent factors involved in knee joint preservation, and any injury or imbalance can impact the knee articular cartilage status and can result in adverse clinical outcomes.➤ Cartilage preservation procedures in the knee will not result in optimal outcomes if there is joint malalignment, meniscal deficiency, or ligamentous instability.➤ Lower-extremity varus or valgus malalignment is a risk factor for the failure of an anterior cruciate ligament (ACL) reconstruction.

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Background: The ulnar collateral ligament (UCL) is a commonly injured elbow stabilizer during throwing. Shear wave elastography (SWE) is a technique that may reveal structural changes in the UCL that are indicative of ligament health and injury risk. The purpose of this study was to assess preseason and inseason shear wave velocity (SWV) in the UCL of collegiate pitchers and to asses repeatability of this measurement technique in healthy volunteers.

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Post-traumatic osteoarthritis (PTOA) is one of the leading causes of disability in developed countries and accounts for 12% of all osteoarthritis cases in the United States. After trauma, inflammatory cells (macrophages amongst others) are quickly recruited within the inflamed synovium and infiltrate the joint space, initiating dysregulation of cartilage tissue homeostasis. Current therapeutic strategies are ineffective, and PTOA remains an open clinical challenge.

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Background: The extent to which concomitant cartilage repair provides an improvement in clinical outcomes after osteotomy is unclear.

Purpose: To compare studies reporting clinical outcomes after isolated osteotomy with or without cartilage repair for osteoarthritis (OA) or focal chondral defects (FCDs) of the knee joint.

Study Design: Systematic review; Level of evidence, 4.

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Background: As blood flow restriction (BFR) utilization continues to rise, it is crucial to define optimal parameters for use. Currently unknown are the effects of occlusion level during BFR on muscle activity in the proximal shoulder.

Purpose/hypothesis: The purpose of this study was to compare electromyographic amplitude (EMGa) of shoulder musculature during exercise using limb occlusion percentages (LOPs).

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Article Synopsis
  • The study aimed to analyze whether performing an osteotomy alongside cartilage repair in the tibiofemoral joint leads to better clinical outcomes compared to cartilage repair alone.
  • It involved a systematic review of 5 studies with a total of 2,267 patients, comparing outcomes such as reoperation rates, complications, and patient satisfaction.
  • Results indicated that patients undergoing cartilage repair with osteotomy (group B) generally showed better outcomes in terms of patient-reported measures compared to those who had cartilage repair without osteotomy (group A).
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Background: Recent evidence indicates that combined upper extremity blood flow restriction (BFR, applied distally to the shoulder) and low-load resistance exercise (LIX) augments clinically meaningful responses in shoulder region tissues proximal to the occlusion site. The purpose of this investigation was to determine the efficacy of BFR-LIX for the shoulder when added to standard offseason training in Division IA collegiate baseball pitchers. We hypothesized that BFR-LIX would augment training-induced increases in shoulder-region lean mass, rotator cuff strength, and endurance.

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Purpose: To systematically review the literature to compare the efficacy and safety of platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and hyaluronic acid (HA) injections for the treatment of knee osteoarthritis (OA).

Methods: A systematic review was performed by searching PubMed, the Cochrane Library, and Embase to identify Level I studies that compared the clinical efficacy of at least 2 of the following 3 injection therapies: PRP, BMAC, and HA for knee OA. The search phrase used was knee AND osteoarthritis AND randomized AND ("platelet rich plasma" OR "bone marrow aspirate" OR "hyaluronic acid").

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Background: Some studies have suggested that running increases the risk of knee osteoarthritis (OA), while others believe it serves a protective function.

Purpose: To perform an updated systematic review of the literature to determine the effects of running on the development of knee OA.

Study Design: Systematic review; Level of evidence, 4.

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Background: Multiple studies have compared outcomes among patients undergoing revision anterior cruciate ligament reconstruction (ACLR) with autograft versus allograft, but these data are inconsistently reported and long-term outcomes depending on graft type are yet to be determined.

Purpose: To perform a systematic review of clinical outcomes after revision ACLR (rACLR) with autograft versus allograft.

Study Design: Systematic review; Level of evidence, 4.

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Purpose: To perform a systematic review of postoperative rehabilitation protocols for third-generation autologous chondrocyte implantation (ACI) of the knee joint.

Methods: A systematic review was performed by searching PubMed, Cochrane Library, and EMBASE to locate randomized controlled trials that described a rehabilitation protocol following third-generation ACI of the knee joint. The search terms used were: "autologous" AND "chondrocyte" AND "randomized".

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Osteosarcoma (OS) is the most common bone tumor in pediatrics. After resection, allografts or metal endoprostheses reconstruct bone voids, and systemic chemotherapy is used to prevent recurrence. This urges the development of novel treatment options for the regeneration of bone after excision.

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