NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.

The interaction between clonally distributed inhibitory receptors and their activating counterparts on NK cells and HLA class I molecules defines NK cell functions, but the role of HLA class I ligands in the acquisition of their receptors during NK development is still unclear. Although some studies demonstrated that HLA-C affects the expression of killer Ig-like receptors (KIR), other studies showed that NK cells acquire their KIR repertoire in a stochastic manner. Only when infected with human CMV is an expansion of self-specific KIR(+) NKG2C(+) NK cells detected.

Cryoglobulinemia revealed by a Purtscher-like retinopathy.

Purpose: To demonstrate the importance of collaboration between ophthalmologists and internists.

Design: Cryoglobulinemia is a systemic vascularite. Ophthalmologic complications are rare and not well known.