Alcohol intake and risk of incident psoriasis in US women: a prospective study.

Objectives: To evaluate the independent association between alcohol consumption and risk of developing psoriasis and to determine if this risk is associated with different types of alcoholic beverages.

Design: A prospective study of female nurses who were followed up from 1991 to 2005.

Setting: Nurses' Health Study II, a cohort of 116,671 US women aged 27 to 44 years in 1991.

Validity, reliability, and sensitivity-to-change properties of the psoriatic arthritis screening and evaluation questionnaire.

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with irreversible joint damage in a subset of individuals. There is a need to screen early for this condition to prevent damage. To meet this need, we have developed the psoriatic arthritis screening and evaluation (PASE) questionnaire.

Wild-type blocking polymerase chain reaction for detection of single nucleotide minority mutations from clinical specimens.

Detection and sequencing of mutations from clinical specimens is often complicated by the presence of an excess of nonmutated cells. To facilitate the detection and sequencing of minority mutations from clinical specimens, we developed wild-type blocking polymerase chain reaction (WTB-PCR). This technique allows sensitive detection of minority mutations in a tissue sample containing excess wild-type DNA.