Publications by authors named "Patrick Kloskowski"
Cyclic di-AMP (c-di-AMP) is an essential secondary messenger regulating cell wall homeostasis and myriads of physiological processes in several Gram-positive and mycobacteria, including human pathogens. Hence, c-di-AMP synthesizing enzymes (DACs) have become a promising antibacterial drug target. To overcome a scarcity of small molecule inhibitors of c-di-AMP synthesizing enzyme CdaA, a computer-aided design of a new compound that should block the enzyme has been performed.
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- - Disulfide bonds in proteins, formed by cysteine residues, play key roles in maintaining protein structure, stability, and function, while also being involved in redox reactions and cellular signaling amidst oxidative stress.
- - This study identifies a novel covalent crosslink (NOS bridge) between a cysteine and a lysine residue in the transaldolase enzyme of Neisseria gonorrhoeae, which functions as an allosteric redox switch to enhance enzymatic activity significantly.
- - The research highlights that this redox switch mechanism is conserved in related enzymes from other pathogens and indicates the presence of similar NOS bridges in diverse proteins across different life forms, suggesting a broader regulatory role.
We present the genome sequence of strain JH1, which belongs to the acetic acid bacteria. The draft genome sequence consists of 3.7 Mb and contains 3,437 predicted protein-encoding genes.
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