Publications by authors named "Patrick Jean-Phillippe"
Article Synopsis
- Infants born to HIV-positive mothers in high tuberculosis regions are at risk for tuberculosis infection, and the study examines the effects of isoniazid preventive therapy initiated during pregnancy versus postpartum.
- The TB APPRISE trial was conducted across eight countries involving 956 mothers, comparing immediate isoniazid therapy during pregnancy to deferred therapy postpartum, and assessed the tuberculosis test results of their infants at 44 weeks.
- The analysis included 749 mother-infant pairs, aiming to evaluate the proportion of infants testing positive for tuberculosis and the predictors of positivity based on the timing of their mothers' isoniazid treatments.
Effect of pregnancy versus postpartum maternal isoniazid preventive therapy on infant growth in HIV-exposed uninfected infants: a post-hoc analysis of the TB APPRISE trial.
EClinicalMedicine
April 2023
Background: Isoniazid preventive therapy (IPT) initiation during pregnancy was associated with increased incidence of adverse pregnancy outcomes in the TB APPRISE trial. Effects of IPT exposure on infant growth are unknown.
Methods: This post-hoc analysis used data from the TB APPRISE trial, a multicentre, double-blind, placebo-controlled trial, which randomised women to 28-week IPT starting in pregnancy (pregnancy-IPT) or postpartum week 12 (postpartum-IPT) in eight countries with high tuberculosis prevalence.
Objective And Design: Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low-income and middle-income countries. We compared neuropsychological outcomes at enrollment (>5 years age) among HIV+, HIV perinatally exposed uninfected (HEU), and HIV unexposed uninfected (HUU) children from four sub-Saharan countries.
Methods: IMPAACT P1060 compared nevirapine versus lopinavir/ritonavir-based antiretroviral treatment (ART) in HIV-infected children 6-35 months of age.