Publications by authors named "Patrick J Montoya"
The large, densely packed artificial surface area of artificial lungs results in rapid clotting and device failure. Surface generated nitric oxide (NO) can be used to reduce platelet activation and coagulation on gas exchange fibers, while not inducing patient bleeding due to its short half-life in blood. To generate NO, artificial lungs can be manufactured with PDMS hollow fibers embedded with copper nanoparticles (Cu NP) and supplied with an infusion of the NO donor S-nitroso-N-acetyl-penicillamine (SNAP).
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- Hollow fiber artificial lungs show promise for long-term use, but clot formation currently limits their functionality to 1-2 weeks.
- This study tested new nitric oxide generating (NOgen) hollow fibers, which included copper particles to produce NO, and found these fibers significantly reduced clotting compared to control fibers.
- Results indicated that NOgen circuits maintained higher blood flow and lower resistance, while showing lower platelet counts and plasma fibrinogen concentrations, suggesting NOgen fibers could effectively manage coagulation in artificial lungs.