Publications by authors named "Patrick J Kane"
Entering pregnancy with a history of adversity, including adverse childhood experiences and racial discrimination stress, is a predictor of negative maternal and fetal health outcomes. Little is known about the biological mechanisms by which preconception adverse experiences are stored and impact future offspring health outcomes. In our maternal preconception stress (MPS) model, female mice underwent chronic stress from postnatal days 28-70 and were mated 2 weeks post-stress.
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- Newborns acquire maternal microbiota during birth, which is crucial for their health and development, but the individual differences in these microbial communities and their impacts on health are not fully understood.
- Researchers created a model using fetal mice that mimics the microbial exposure of vaginal birth, showing significant effects on metabolism, immunity, and brain development in offspring based on the specific communities introduced.
- The study found that an unhealthy prenatal environment (like maternal obesity or dysbiosis) can worsen health outcomes and increase mortality in offspring, highlighting the importance of the maternal microbiome and prenatal conditions on later health.
Women who have experienced adverse childhood events (ACEs) around puberty are at the greatest risk for neuropsychiatric disorders across the lifespan. This population is exceptionally vulnerable to neuropsychiatric disease presentation during the hormonally dynamic state of pregnancy. We previously established that chronic adversity around puberty in female mice significantly altered their HPA axis function specifically during pregnancy, modeling the effects of pubertal ACEs we also reported in women.
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